Dr. Shen earned his Ph.D. in Biochemistry and Molecular Biology from Chinese Academy of Sciences in 2014, where he focused on cancer mechanistic study and drug screens. He then worked as a drug development scientist at AstraZeneca Pharmaceuticals. Dr. Shen pursued postdoctoral training at the NCI-Designated Cancer Center at Sanford Burnham Prebys Medical Discovery Institute in La Jolla, California, with a focus on functional genomics and targeting tumor-intrinsic mechanisms to augment cancer immunotherapy responses. In 2020, he was promoted to a Staff Scientist position at the Cancer Center, where his research delved into the crosstalk of cancer stem cells and the tumor immune microenvironment. In 2023, Dr. Shen joined the IU School of Medicine as an Assistant Professor in the Department of Medical and Molecular Genetics and the Medical Sciences Program. His laboratory utilizes various patient-derived samples and employs a combination of bioinformatic and experimental techniques, including functional genomics, single-cell and spatial omics, mouse models, and drug screens, to unveil the mechanisms of cancer stem cell maintenance and resistance to immunosurveillance, with the goal of developing cancer stem cell-based targeted therapies and immunotherapies for brain and other cancers.