17300-Jacob, Seethal

Seethal A. Jacob, MD

Assistant Professor of Pediatrics

Phone 317-278-9662
705 Riley Hospital Drive
ROC 4340

Indianapolis, IN 46202
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Dr. Seethal Jacob is an Assistant Professor of Pediatrics.  She graduated from Wright State Boonshoft School of Medicine in 2009 and completed her pediatric residency and chief residency at Indiana University School of Medicine.  She went on to complete a fellowship in Pediatric Hematology-Oncology, as well as a Masters in Clinical Research at the University of Pittsburgh, where she began researching the genetic association of sickle cell disease and its various complications.  After fellowship, she returned to Indiana University/Riley Hospital for Children as part of the Pediatric and Adolescent Comparative Effectiveness Research (PACER) group and Director of the Comprehensive Pediatric Sickle Cell Program at Riley.  Her research focuses on developing and evaluating interventions, such as telehealth, to improve access to and the quality of care for children living with sickle cell disease.

Key Publications

Jacob SA, Talati R, Kanter J. The evolving treatment landscape for children with sickle cell disease. Lancet Child Adolesc Health. 2023 Nov;7(11):797-808. doi: 10.1016/S2352-4642(23)00201-8. Review. PubMed PMID: 37858508.

Jacob SA, Bouck J, Daas R, Jackson MD, LaMotte JE, Carroll AE. Understanding caregiver burden with accessing sickle cell care in the Midwest and their perspective on telemedicine. BMC Health Serv Res. 2023 May 17;23(1):500. doi: 10.1186/s12913-023-09383-x. PubMed PMID: 37198614; PubMed Central PMCID: PMC10189684.

Jacob SA, Carroll AE, Bennett WE Jr. A feasibility study of telemedicine for paediatric sickle cell patients living in a rural medically underserved area. J Telemed Telecare. 2021 Aug;27(7):431-435. doi: 10.1177/1357633X19883558. Epub 2019 Nov 6. PubMed PMID: 31694482; PubMed Central PMCID: PMC8934441.

Jacob SA, Meier ER. Importance of sickle cell trait counseling for adolescents and young adults.Pediatr Blood Cancer. 2021 Dec;68(12):e29300. doi: 10.1002/pbc.29300. Epub 2021 Aug 16. PubMed PMID: 34399031; PubMed Central PMCID: PMC8965882.

Martin OY, Thompson SM, Carroll AE, Jacob SA. Emergency Department Provider Survey Regarding Acute Sickle Cell Pain Management. J Pediatr Hematol Oncol. 2020 Aug;42(6):375-380. doi: 10.1097/MPH.0000000000001843. PubMed PMID: 32569034; PubMed Central PMCID: PMC9024381.

Jacob SA, Novelli EM, Isenberg JS, Garrett ME, Chu Y, Soldano K, Ataga KI, Telen MJ, Ashley-Koch A, Gladwin MT, et al. Thrombospondin-1 gene polymorphism is associated with estimated pulmonary artery pressure in patients with sickle cell anemia. Am J Hematol. 2017 Mar;92(3):E31-E34. doi: 10.1002/ajh.24635



Titles & Appointments

  • Assistant Professor of Pediatrics
  • Education
    2016 MS University of Pittsburgh
    2015 Fellowship Children's Hospital of Pittsburgh
    2012 Residency Indiana University School of Medicine
    2009 MD Wright State University
    2005 BS University of Notre Dame
  • Research


    Dr. Jacob’s primary area of research interest is in healthcare access and delivery for patients living with sickle cell disease, with a particular focus on implementation of health interventions utilizing population input in the Learning Health System.  She was an AHRQ/PCORI Learning Health System K12 scholar and has since been awarded a K23 from the NHLBI to develop and evaluate telemedicine models for the delivery of sickle cell care in Indiana. She has received additional funding from Indiana University, the state, and foundational groups to improve healthcare equity for individuals living with sickle cell disease.


  • Professional Organizations
    American Academy of Pediatrics
    American Society of Hematology
    American Society of Pediatric Hematology/Oncology
    Foundation for Women and Girls with Blood Disorders Learning Action Network
  • Board Certifications
    American Board of Pediatrics - Pediatric Hematology-Oncology
    American Board of Pediatrics - Pediatrics
  • Clinical Interests

    Dr. Jacob cares for a variety of patients with blood disorders, but her primary area of interest is in caring for patients with sickle cell disease as part of Riley’s Comprehensive Sickle Cell Program.  Other areas of interest include thalassemia and other red cell disorders.


  • Awards
    Org: Alpha Omega Alpha
    Desc: Honor Society
    Scope: State
    Date: 2022-01-01
    Desc: Trustee Teaching Award
    Scope: University
    Date: 2021-05-01
    Org: Indiana University School of Medicine
    Desc: Gold Humanism Honor Society
    Scope: University
    Date: 2008-01-01

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