Experts at Indiana University School of Medicine have helped identify that a common protein found in neurodegenerative diseases forms amyloid filaments in an age-dependent manner without a connection to disease.
Indiana University School of Medicine researchers are making new discoveries about the pathological changes in people who have inherited Alzheimer’s disease versus developing the disease sporadically. These findings could lead to new ways of preventing and treating the disease.
Investigators from two of Indiana University School of Medicine’s largest funded research programs are collaborating on a study investigating the biology behind a gene associated with Alzheimer’s disease, with the hopes of developing a drug to treat the disease.
When immune cells move throughout the brain, they act as the first line of defense against viruses, toxic materials and damaged neurons, rushing over to clear out them. Researchers at Indiana University School of Medicine have been investigating how these immune cells in the brain—microglia—relate to a gene mutation recently found in Alzheimer’s disease patients.
When the Food and Drug Administration approved the use of the drug aducanumab to treat Alzheimer’s disease in early June, leaders in neurodegeneration research quickly created an expert panel to issue guidance to physicians on how to best administer the drug.
A new $11.2 million grant coordinated by the Indiana University School of Medicine from the National Institute on Aging (NIA) will support an international collaboration on multiethnic genomic analysis and advanced brain imaging and other biomarkers for early detection of Alzheimer’s disease.