The Mechanobiology & Muscle-Bone Crosstalk Team

Bone and muscle couple mechanical and biochemical stimulation to effect cellular responses through signal transduction. They also act as endocrine/secretory organs by releasing soluble factors, such as osteokines and myokines. The mechanobiology and muscle-bone crosstalk research team utilizes molecular, cellular, systemic and organismal level functional outcomes to investigate mutual interactions between bone and muscle. Given many physiological processes are regulated by bone and muscle in a paracrine manner, our group also investigates distant tissues in development, normal physiology and disease.