7391-Duman Scheel, Molly

Molly Duman Scheel, PhD

Navari Family Professor

Raclin-Carmichael Hall
1234 Notre Dame Ave.

South Bend, IN 46617
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2020-present, Navari Family Professor,  Department of Medical and Molecular Genetics, IU School of Medicine-South Bend

2008-Present, Eck Institute for Global Health, University of Notre Dame

2013-2020, Associate Professor, Department of Medical and Molecular Genetics, IU School of Medicine-South Bend

2013-2020, Adjunct Associate Professor, Department of Biological Sciences, University of Notre Dame


2007-2013, Assistant Professor, Department of Medical and Molecular Genetics, IU School of Medicine-South Bend


2007-2013, Adjunct Assistant Professor, Department of Biological Sciences, University of Notre Dame


2002-2007,  Assistant Professor, Biology Department, Albion College


1999-2002,  Postdoctoral Fellow, University of Chicago, Ben May Institute for Cancer Research, University of Chicago     

Key Publications

Mysore, K., Hapairai, L.K. M., Sun, L., Li, P., Wang, C.W., Scheel, N.D., Lesnik, A., Igiede, J., Scheel, M. P, Wei, N., Severson, D.W, Duman-Scheel, M. 2020. Characterization of a dual-action adulticidal and larvicidal interfering RNA pesticide targeting the Shaker gene of multiple disease vector mosquitoes. PLoS NTD. 14: e0008479. PMID: 32687496. PMCID: PMC7392347.

Stewart, A.T.M., Winter, N., Igiede, J., Hapairai, L.K., James, L.D., Feng, R.S., Mohammed, A., Severson, D.W., Duman-Scheel, M. 2020. Community acceptance of yeast interfering RNA larvicide technology for control of Aedes mosquitoes in Trinidad. PloS One. 15(8): e0237675. PMID: 32797066. PMCID: PMC7428178.

Wiltshire, R M. and Duman-Scheel, M. 2020. Advances in oral RNAi for disease vector mosquito research and control.  Current Opinion Insect Sci. 40: 18-23.  PMID: 32516723.


Titles & Appointments

  • Navari Family Professor
  • Professor of Medical & Molecular Genetics
  • Education
    1999 PhD University of Chicago
    1994 BS University of Notre Dame
  • Research

         Vector mosquitoes inflict more human suffering than any other organism—and kill more than one million people each year.  Despite the devastating impact of these insects on human society, we know very little about mosquito developmental biology.  Our laboratory’s in-depth analysis of mosquito developmental genetics aims to promote the elucidation of tools to target mosquitoes before they are disease-transmitting adults.  Research in our lab, which has primarily focused on analysis of mosquito central and sensory nervous system development, has included the first-ever targeted genetic knockdown studies of mosquito neural development.  In recent years, we have begun a large-scale effort to develop species-specific interfering RNA insecticides, a promising new tool for the biorational control of mosquitoes.  

    Lab members and Contact Information:

    Keshava Mysore, Research Asst. Professor, kmysore@iu.edu

    Joe Roethele, Research Associate, jroethe@iu.edu

    Ping Li, Research Technician, pli@nd.edu

    Longhua Sun, Research Technician, Longhua.Sun.15@nd.edu

    Joi Misenti, Research Technician, jmisenti@iu.edu

    Laboratory phone:  (574) 631-7194

  • Professional Organizations
    American Committee on Medical Entomology
    American Mosquito Control Association
    American Society of Tropical Medicine and Hygiene
    Entomological Society of America
    Genetics Society of America
    Society for Developmental Biology
  • Awards
    Org: Indiana University School of Medicine
    Desc: Trustees Teaching Award
    Scope: University
    Date: 2020-05-01
    Org: NIH/NIAID
    Desc: Functional assessment of the regulation of mosquito sexual dimorphism by non-coding RNAs 1 R21 AI144256-01
    Scope: National
    Date: 2019-02-01
    Org: National Institutes of Health
    Desc: Development of yeast interfering RNA larvicides targeting Aedes aegypti, 1 R21 AI128116-01
    Scope: National
    Date: 2017-07-21
    Org: Deployed Warfighter Protection Program (DoD)
    Desc: Dual action larvicidal/adulticidal siRNA insecticides for biorational mosquito control, W911QY-17-1-0002
    Scope: National
    Date: 2017-07-10
    Org: USAID
    Desc: Combating Zika and Future Threats, A Grand Challenge for Development (Completed)
    Scope: International
    Date: 2016-10-01
    Org: Showalter Trust
    Desc: Showalter Scholar Award
    Scope: University
    Date: 2015-08-01
    Org: Bill and Melinda Gates Foundation
    Desc: Grand Challenges and Explorations Phase 1 Grant Award (Completed)
    Scope: International
    Date: 2015-06-01
    Org: IUPUI
    Desc: Trailblazer Award
    Scope: University
    Date: 2015-04-01
    Org: NIH/NIAID
    Desc: Cis-regulatory element discovery in a sequenced mosquito genome (Completed)
    Scope: National
    Date: 2015-01-01
    Org: NIH/NIAID
    Desc: R01AI081795-01 (Completed)
    Scope: National
    Date: 2009-08-01

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