Jay L. Hess, MD, PhD, MHSA
Executive Vice President for University Clinical Affairs
Indianapolis, IN 46202
Jay L. Hess, MD, PhD, MHSA, joined Indiana University School of Medicine in 2013 as its 10th dean.
He is responsible for the largest medical school in the United States, with nine campuses, more than 2,000 students, and nearly 7,200 full-time, part-time and volunteer faculty. In addition, he serves as one of four executive vice presidents of Indiana University and is charged with guiding the university’s clinical affairs strategy.
Since becoming dean, he has overseen a 125 percent increase in research funding from the National Institutes of Health, led the school through a comprehensive curriculum reform and successful reaccreditation, and strengthened the relationship with IU Health, its primary clinical partner and one of the nation’s premier academic medical centers. A physician-scientist, Hess is driven to improve care for patients and is guided by a commitment to transforming health in Indiana and around the world.
IU School of Medicine’s major initiatives under Hess’ leadership have included:
- Leading the charge to safely return students, faculty and staff to Indiana University campuses statewide after the unprecedented suspension of most in-person research and instruction at the start of the COVID-19 health crisis
- Enacting a single curriculum that includes interprofessional education and the opportunity to pursue scholarly concentrations on all campuses
- Investing in new educational and research facilities across the state
- Moving over 65 independent physician groups into a single faculty group practice, IU Health Physicians, to improve delivery of care and strengthen the alignment of clinical, education and research missions
- Implementing the IU Precision Health Initiative, a bold plan to develop new therapies and improve outcomes for patients with multiple myeloma, triple negative breast cancer, diabetes, childhood sarcoma and Alzheimer’s disease
- Bringing leading-edge therapies to Indiana, including genomically-guided therapies and CAR-T immunotherapy
- Securing prestigious Comprehensive status for the Indiana University Melvin and Bren Simon Cancer Center from the National Cancer Institute
- Expanding residency positions to increase the number of physicians who train and practice in Indiana
- Recruiting top-flight leaders, including 21 new department chairs and five research center and institute directors, both from within IU School of Medicine and from other top tier institutions
- Advancing diversity, inclusiveness and wellness of the faculty, staff and learners
- Raising over $1.7 billion as part of For All: The Indiana University Bicentennial Campaign with a focus on endowing chairs, professorships and scholarships
- Developing institution-wide strategic plans in 2014, 2018 and 2022
Education and Career Highlights
Hess earned his medical and doctorate degrees from the Johns Hopkins University School of Medicine and completed residency training in anatomic pathology and fellowships in hematopathology and surgical pathology at Brigham and Women’s Hospital. He holds a certificate in business administration from The Wharton School of the University of Pennsylvania, and a master’s degree in health services administration from the University of Michigan School of Public Health.
Before moving to Indiana, Hess served for eight years as the Carl V. Weller Professor and chair of the Department of Pathology and professor of pathology and internal medicine at the University of Michigan. He previously served as director of hematopathology at the University of Pennsylvania and as assistant professor of pathology at Washington University School of Medicine.
Titles & Appointments
- Executive Vice President for University Clinical Affairs
- Dean, School of Medicine
- Director, Indiana Statewide Medical Education System
- Walter J. Daly Professor
- Professor of Pathology & Laboratory Medicine
- Professor of Medicine
- Adjunct Professor, School of Public Health
Education2012 MHSA University of Michigan1989 MD Johns Hopkins University1989 PhD Johns Hopkins University1982 BA Johns Hopkins University
A board-certified Hematopathologist and author of more than 100 scientific papers and book chapters, Dr. Hess is considered one of the nation’s leaders in the epigenetics of leukemia. His laboratory has done some of the most seminal work on the mechanisms of transformation by the mixed-lineage leukemia protein MLL and its downstream targets, the HOX proteins. While Chair at Michigan, Dr. Hess assembled and led an interdisciplinary research team working to develop epigenetically targeted therapeutics for acute leukemia. He continues to run an active NIH-funded research laboratory.
In 2007, Dr. Hess helped establish the Michigan Center for Translational Pathology led by Dr. Arul Chinnaiyan, one of the leading research centers for biomarker discovery in the nation. He created one of the first pathology informatics divisions in the nation and led the University of Michigan Health Care System strategy implementation in personalized medicine.
PublicationsDeregulation of the HOXA9/MEIS1 axis in acute leukemia.
Collins CT; Hess JL; Current opinion in hematology 2016 JulPRDM16 Suppresses MLL1r Leukemia via Intrinsic Histone Methyltransferase Activity.
Zhou B; Wang J; Lee SY; Xiong J; Bhanu N; Guo Q; Ma P; Sun Y; Rao RC; Garcia BA; Hess JL; Dou Y; Molecular cell 2016 Apr 12A splicing-regulatory polymorphism in DRD2 disrupts ZRANB2 binding, impairs cognitive functioning and increases risk for schizophrenia in six Han Chinese samples.
Cohen OS; Weickert TW; Hess JL; Paish LM; McCoy SY; Rothmond DA; Galletly C; Liu D; Weinberg DD; Huang XF; Xu Q; Shen Y; Zhang D; Yue W; Yan J; Wang L; Lu T; He L; Shi Y; Xu M; Che R; Tang W; Chen CH; Chang WH; Hwu HG; Liu CM; Liu YL; Wen CC; Fann CS; Chang CC; Kanazawa T; Middleton FA; Duncan TM; Faraone SV; Weickert CS; Tsuang MT; Glatt SJ; Molecular psychiatry 2015 Sep 8The influence of genes on "positive valence systems" constructs: A systematic review.
Hess JL; Kawaguchi DM; Wagner KE; Faraone SV; Glatt SJ; American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2015 Sep 14Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo.
Borkin D; He S; Miao H; Kempinska K; Pollock J; Chase J; Purohit T; Malik B; Zhao T; Wang J; Wen B; Zong H; Jones M; Danet-Desnoyers G; Guzman ML; Talpaz M; Bixby DL; Sun D; Hess JL; Muntean AG; Maillard I; Cierpicki T; Grembecka J; Cancer cell 2015 Mar 26Role of HOXA9 in leukemia: dysregulation, cofactors and essential targets.
Collins CT; Hess JL; Oncogene 2015 Jun 1Bioinformatic analyses and conceptual synthesis of evidence linking ZNF804A to risk for schizophrenia and bipolar disorder.
Hess JL; Quinn TP; Akbarian S; Glatt SJ; American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2015 JanThe same site on the integrase-binding domain of lens epithelium-derived growth factor is a therapeutic target for MLL leukemia and HIV.
Murai MJ; Pollock J; He S; Miao H; Purohit T; Yokom A; Hess JL; Muntean AG; Grembecka J; Cierpicki T; Blood 2014 Oct 10C/EBPa is an essential collaborator in Hoxa9/Meis1-mediated leukemogenesis.
Collins C; Wang J; Miao H; Bronstein J; Nawer H; Xu T; Figueroa M; Muntean AG; Hess JL; Proceedings of the National Academy of Sciences of the United States of America 2014 Jun 23Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia.
Cao F; Townsend EC; Karatas H; Xu J; Li L; Lee S; Liu L; Chen Y; Ouillette P; Zhu J; Hess JL; Atadja P; Lei M; Qin ZS; Malek S; Wang S; Dou Y; Molecular cell 2014 Jan 2Targeting recruitment of disruptor of telomeric silencing 1-like (DOT1L): characterizing the interactions between DOT1L and mixed lineage leukemia (MLL) fusion proteins.
Shen C; Jo SY; Liao C; Hess JL; Nikolovska-Coleska Z; The Journal of biological chemistry 2013 Sep 1How might ZNF804A variants influence risk for schizophrenia and bipolar disorder? A literature review, synthesis, and bioinformatic analysis.
Hess JL; Glatt SJ; American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2013 Oct 4MLL fusion protein-driven AML is selectively inhibited by targeted disruption of the MLL-PAFc interaction.
Muntean AG; Chen W; Jones M; Granowicz EM; Maillard I; Hess JL; Blood 2013 Jul 30MLL-ENL inhibits polycomb repressive complex 1 to achieve efficient transformation of hematopoietic cells.
Maethner E; Garcia-Cuellar MP; Breitinger C; Takacova S; Divoky V; Hess JL; Slany RK; Cell reports 2013 Apr 25A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.
Wang J; Muntean AG; Wu L; Hess JL; The Journal of biological chemistry 2012 Nov 5Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia.
Akalin A; Garrett-Bakelman FE; Kormaksson M; Busuttil J; Zhang L; Khrebtukova I; Milne TA; Huang Y; Biswas D; Hess JL; Allis CD; Roeder RG; Valk PJ; Löwenberg B; Delwel R; Fernandez HF; Paietta E; Tallman MS; Schroth GP; Mason CE; Melnick A; Figueroa ME; PLoS genetics 2012 Jun 21Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia.
Grembecka J; He S; Shi A; Purohit T; Muntean AG; Sorenson RJ; Showalter HD; Murai MJ; Belcher AM; Hartley T; Hess JL; Cierpicki T; Nature chemical biology 2012 Jan 29Twenty-first century pathology sign-out.
Tomlins S; Robinson D; Penny RJ; Hess JL; Clinics in laboratory medicine 2012 DecThe pathogenesis of mixed-lineage leukemia.
Muntean AG; Hess JL; Annual review of pathology 2011 Oct 17Identification and characterization of Hoxa9 binding sites in hematopoietic cells.
Huang Y; Sitwala K; Bronstein J; Sanders D; Dandekar M; Collins C; Robertson G; MacDonald J; Cezard T; Bilenky M; Thiessen N; Zhao Y; Zeng T; Hirst M; Hero A; Jones S; Hess JL; Blood 2011 Nov 9Self-assembly of dinitrosyl iron units into imidazolate-edge-bridged molecular squares: characterization including Mössbauer spectroscopy.
Hess JL; Hsieh CH; Brothers SM; Hall MB; Darensbourg MY; Journal of the American Chemical Society 2011 Nov 29CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis.
Tan J; Jones M; Koseki H; Nakayama M; Muntean AG; Maillard I; Hess JL; Cancer cell 2011 Nov 15Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation.
Jo SY; Granowicz EM; Maillard I; Thomas D; Hess JL; Blood 2011 Feb 25ECSASB2 mediates MLL degradation during hematopoietic differentiation.
Wang J; Muntean AG; Hess JL; Blood 2011 Dec 15N-heterocyclic carbene ligands as mimics of imidazoles/histidine for the stabilization of di- and trinitrosyl iron complexes.
Hess JL; Hsieh CH; Reibenspies JH; Darensbourg MY; Inorganic chemistry 2011 Aug 8MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia.
Monroe SC; Jo SY; Sanders DS; Basrur V; Elenitoba-Johnson KS; Slany RK; Hess JL; Experimental hematology 2010 Sep 18Significance of AF4-MLL reciprocal fusion in t(4;11) leukemias?
Sanders DS; Muntean AG; Hess JL; Leukemia research 2010 Oct 16PAFc, a key player in MLL-rearranged leukemogenesis.
Tan J; Muntean AG; Hess JL; Oncotarget 2010 OctAcute myeloid leukemia diagnosis in the 21st century.
Betz BL; Hess JL; Archives of pathology & laboratory medicine 2010 OctWhat are we anyway? The role of pathologists in the 21st century.
Hess JL; Archives of pathology & laboratory medicine 2010 OctThe PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis.
Muntean AG; Tan J; Sitwala K; Huang Y; Bronstein J; Connelly JA; Basrur V; Elenitoba-Johnson KS; Hess JL; Cancer cell 2010 Jun 15Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia.
Fisher CL; Pineault N; Brookes C; Helgason CD; Ohta H; Bodner C; Hess JL; Humphries RK; Brock HW; Blood 2009 Oct 27Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice.
Fisher CL; Lee I; Bloyer S; Bozza S; Chevalier J; Dahl A; Bodner C; Helgason CD; Hess JL; Humphries RK; Brock HW; Developmental biology 2009 Oct 13Resin-bound models of the [FeFe]-hydrogenase enzyme active site and studies of their reactivity.
Green KN; Hess JL; Thomas CM; Darensbourg MY; Dalton transactions (Cambridge, England : 2003) 2009 Mar 2MLL associates with telomeres and regulates telomeric repeat-containing RNA transcription.
Caslini C; Connelly JA; Serna A; Broccoli D; Hess JL; Molecular and cellular biology 2009 Jun 15What hematopathology tells us about the future of pathology informatics.
Hess JL; Archives of pathology & laboratory medicine 2009 JunEpigenetic dysregulation in cancer.
Muntean AG; Hess JL; The American journal of pathology 2009 Aug 28The role of menin in hematopoiesis.
Maillard I; Hess JL; Advances in experimental medicine and biology 2009Chromatin immunoprecipitation (ChIP) for analysis of histone modifications and chromatin-associated proteins.
Milne TA; Zhao K; Hess JL; Methods in molecular biology (Clifton, N.J.) 2009The PHD fingers of MLL block MLL fusion protein-mediated transformation.
Muntean AG; Giannola D; Udager AM; Hess JL; Blood 2008 Sep 16HOX proteins and leukemia.
Sitwala KV; Dandekar MN; Hess JL; International journal of clinical and experimental pathology 2008 Mar 30MLL-AF9 leukemia stem cells: hardwired or taking cues from the microenvironment?
Muntean AG; Hess JL; Cancer cell 2008 JunElectronic effects of (N2S2)M(NO) complexes (M = Fe, Co) as metallodithiolate ligands.
Hess JL; Conder HL; Green KN; Darensbourg MY; Inorganic chemistry 2008 Feb 9A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification.
Mueller D; Bach C; Zeisig D; Garcia-Cuellar MP; Monroe S; Sreekumar A; Zhou R; Nesvizhskii A; Chinnaiyan A; Hess JL; Slany RK; Blood 2007 Sep 12Immunoglobulin cleavage by the streptococcal cysteine protease IdeS can be detected using protein G capture and mass spectrometry.
Hess JL; Porsch EA; Shertz CA; Boyle MD; Journal of microbiological methods 2007 May 5Mechanisms of transcriptional regulation by MLL and its disruption in acute leukemia.
Dou Y; Hess JL; International journal of hematology 2007 Dec 4Interaction of MLL amino terminal sequences with menin is required for transformation.
Caslini C; Yang Z; El-Osta M; Milne TA; Slany RK; Hess JL; Cancer research 2007 Aug 1MLL core components give the green light to histone methylation.
Crawford BD; Hess JL; ACS chemical biology 2006 Sep 19The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression.
Chen YX; Yan J; Keeshan K; Tubbs AT; Wang H; Silva A; Brown EJ; Hess JL; Pear WS; Hua X; Proceedings of the National Academy of Sciences of the United States of America 2006 Jan 13Fibrinogen fragment D is necessary and sufficient to anchor a surface plasminogen-activating complex in Streptococcus pyogenes.
Hess JL; Boyle MD; Proteomics 2006 Janc-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells.
Hess JL; Bittner CB; Zeisig DT; Bach C; Fuchs U; Borkhardt A; Frampton J; Slany RK; Blood 2006 Feb 28Structural basis of multimer-mediated mayhem.
Sitwala KV; Hess JL; Cancer cell 2006 AprApplication of immunoproteomics to rapid cytokine detection.
Boyle MD; Hess JL; Nuara AA; Buller RM; Methods (San Diego, Calif.) 2006 AprMLL associates specifically with a subset of transcriptionally active target genes.
Milne TA; Dou Y; Martin ME; Brock HW; Roeder RG; Hess JL; Proceedings of the National Academy of Sciences of the United States of America 2005 Sep 30Practical applications of high-affinity, albumin-binding proteins from a group G streptococcal isolate.
Coyle EM; Blazer LL; White AA; Hess JL; Boyle MD; Applied microbiology and biotechnology 2005 Oct 27Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.
Dou Y; Milne TA; Tackett AJ; Smith ER; Fukuda A; Wysocka J; Allis CD; Chait BT; Hess JL; Roeder RG; Cell 2005 Jun 17Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors.
Milne TA; Hughes CM; Lloyd R; Yang Z; Rozenblatt-Rosen O; Dou Y; Schnepp RW; Krankel C; Livolsi VA; Gibbs D; Hua X; Roeder RG; Meyerson M; Hess JL; Proceedings of the National Academy of Sciences of the United States of America 2005 Jan 7Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.
Wang J; Iwasaki H; Krivtsov A; Febbo PG; Thorner AR; Ernst P; Anastasiadou E; Kutok JL; Kogan SC; Zinkel SS; Fisher JK; Hess JL; Golub TR; Armstrong SA; Akashi K; Korsmeyer SJ; The EMBO journal 2005 Jan 6Immunoproteomics.
Hess JL; Blazer L; Romer T; Faber L; Buller RM; Boyle MD; Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005 Feb 5Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications.
Milne TA; Martin ME; Brock HW; Slany RK; Hess JL; Cancer research 2005 Dec 15Murine gammaherpesvirus 68 infection is associated with lymphoproliferative disease and lymphoma in BALB beta2 microglobulin-deficient mice.
Tarakanova VL; Suarez F; Tibbetts SA; Jacoby MA; Weck KE; Hess JL; Speck SH; Virgin HW 4th; Journal of virology 2005 DecThe eleven-nineteen-leukemia protein ENL connects nuclear MLL fusion partners with chromatin.
Zeisig DT; Bittner CB; Zeisig BB; García-Cuéllar MP; Hess JL; Slany RK; Oncogene 2005 Aug 18MLL: a histone methyltransferase disrupted in leukemia.
Hess JL; Trends in molecular medicine 2004 OctFusion-protein truncation provides new insights into leukemogenesis.
Hess JL; Hug BA; Proceedings of the National Academy of Sciences of the United States of America 2004 Nov 30Telomerase activity measurement in magnetically captured epithelial cells: comparison of slab-gel and capillary electrophoresis.
Hess JL; Atha DH; Xu JF; Highsmith WE Jr; Electrophoresis 2004 JunHoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.
Zeisig BB; Milne T; García-Cuéllar MP; Schreiner S; Martin ME; Fuchs U; Borkhardt A; Chanda SK; Walker J; Soden R; Hess JL; Slany RK; Molecular and cellular biology 2004 JanMenin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.
Hughes CM; Rozenblatt-Rosen O; Milne TA; Copeland TD; Levine SS; Lee JC; Hayes DN; Shanmugam KS; Bhattacharjee A; Biondi CA; Kay GF; Hayward NK; Hess JL; Meyerson M; Molecular cell 2004 Feb 27Effects of the proteasome inhibitor PS-341 on tumor growth in HTLV-1 Tax transgenic mice and Tax tumor transplants.
Mitra-Kaushik S; Harding JC; Hess JL; Ratner L; Blood 2004 Apr 15Mechanisms of transformation by MLL.
Hess JL; Critical reviews in eukaryotic gene expression 2004Dimerization of MLL fusion proteins immortalizes hematopoietic cells.
Martin ME; Milne TA; Bloyer S; Galoian K; Shen W; Gibbs D; Brock HW; Slany R; Hess JL; Cancer cell 2003 SepHigh-throughput analysis of telomerase by capillary electrophoresis.
Atha DH; Miller K; Sanow AD; Xu J; Hess JL; Wu OC; Wang W; Srivastava S; Highsmith WE; Electrophoresis 2003 JanThe Cancer Genome Anatomy Project: power tools for cancer biologists.
Hess JL; Cancer investigation 2003 AprTrp53 sequence analysis of L5178Y cell line derivatives.
Hess JL; Clark LS; Moore MM; Environmental and molecular mutagenesis 2003MLL targets SET domain methyltransferase activity to Hox gene promoters.
Milne TA; Briggs SD; Brock HW; Martin ME; Gibbs D; Allis CD; Hess JL; Molecular cell 2002 NovThe advent of targeted therapeutics and implications for pathologists.
Hess JL; American journal of clinical pathology 2002 MarTelomerase detection in body fluids.
Hess JL; Highsmith WE Jr; Clinical chemistry 2002 JanMolecular genetics of benign tumors.
Hess JL; Kossev P; Cancer investigation 2002Chronic myelogenous leukemia: laboratory diagnosis and monitoring.
Wang YL; Bagg A; Pear W; Nowell PC; Hess JL; Genes, chromosomes & cancer 2001 OctAnalysis of p53 inactivation in a human T-cell leukemia virus type 1 Tax transgenic mouse model.
Portis T; Grossman WJ; Harding JC; Hess JL; Ratner L; Journal of virology 2001 MarPathologic, cytogenetic and molecular assessment of acute promyelocytic leukemia patients treated with arsenic trioxide (As2O3).
Zhang T; Westervelt P; Hess JL; Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2000 SepQuiz case 2. Natural killer (NK) cell/peripheral T-cell lymphoma.
Khariwala SS; Litman DA; McQuone SJ; Hess JL; Thaler ER; Archives of otolaryngology--head & neck surgery 2000 NovThe amino terminus targets the mixed lineage leukemia (MLL) protein to the nucleolus, nuclear matrix and mitotic chromosomal scaffolds.
Caslini C; Alarcòn AS; Hess JL; Tanaka R; Murti KG; Biondi A; Leukemia 2000 NovThe amino terminus of the mixed lineage leukemia protein (MLL) promotes cell cycle arrest and monocytic differentiation.
Caslini C; Shilatifard A; Yang L; Hess JL; Proceedings of the National Academy of Sciences of the United States of America 2000 Mar 14Transformation of monocytoid B-cell lymphoma to large cell lymphoma associated with crystal-storing histiocytes.
Thorson P; Hess JL; Archives of pathology & laboratory medicine 2000 MarA carboxy-terminal domain of ELL is required and sufficient for immortalization of myeloid progenitors by MLL-ELL.
DiMartino JF; Miller T; Ayton PM; Landewe T; Hess JL; Cleary ML; Shilatifard A; Blood 2000 Dec 1Sixth nerve palsy as a presenting sign of intracranial plasmacytoma and multiple myeloma.
Movsas TZ; Balcer LJ; Eggenberger ER; Hess JL; Galetta SL; Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2000 DecThe murine gammaherpesvirus 68 v-cyclin gene is an oncogene that promotes cell cycle progression in primary lymphocytes.
van Dyk LF; Hess JL; Katz JD; Jacoby M; Speck SH; Virgin HW IV; Journal of virology 1999 JunAcute promyelocytic leukemia with additional chromosomal abnormalities and absence of Auer rods.
Kaleem Z; Watson MS; Zutter MM; Blinder MA; Hess JL; American journal of clinical pathology 1999 JulMammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development.
Hanson RD; Hess JL; Yu BD; Ernst P; van Lohuizen M; Berns A; van der Lugt NM; Shashikant CS; Ruddle FH; Seto M; Korsmeyer SJ; Proceedings of the National Academy of Sciences of the United States of America 1999 Dec 7MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis.
Yu BD; Hanson RD; Hess JL; Horning SE; Korsmeyer SJ; Proceedings of the National Academy of Sciences of the United States of America 1998 Sep 1Life, death and nuclear spots.
Hess JL; Korsmeyer SJ; Nature genetics 1998 NovBone marrow staging in patients with non-Hodgkin's lymphoma: is flow cytometry a useful test?
Naughton MJ; Hess JL; Zutter MM; Bartlett NL; Cancer 1998 Mar 15Chromosomal translocations in benign tumors: the HMGI proteins.
Hess JL; American journal of clinical pathology 1998 MarDetection of chromosomal translocations in leukemia. Is there a best way?
Hess JL; American journal of clinical pathology 1998 JanGuidelines for the diagnosis of leukemia or lymphoma in children.
Zutter MM; Hess JL; American journal of clinical pathology 1998 AprDefects in yolk sac hematopoiesis in Mll-null embryos.
Hess JL; Yu BD; Li B; Hanson R; Korsmeyer SJ; Blood 1997 Sep 1Free amino acids reflect impact of selenite-dependent stress on primary metabolism in rat lens.
Mitton KP; Hess JL; Bunce GE; Current eye research 1997 OctMalignant hematopoietic breast tumors.
Lin Y; Govindan R; Hess JL; American journal of clinical pathology 1997 FebBlastic transformation of mantle cell lymphoma.
Kaleem Z; Wakoff AR; Smith RP; Hess JL; Archives of pathology & laboratory medicine 1996 JunJuvenile chronic myelogenous leukemia.
Hess JL; Zutter MM; Castleberry RP; Emanuel PD; American journal of clinical pathology 1996 FebPrecataractous changes affect lens transparency in the selenite cataract.
Hess JL; Mitton KP; Bunce GE; Ophthalmic research 1996Altered Hox expression and segmental identity in Mll-mutant mice.
Yu BD; Hess JL; Horning SE; Brown GA; Korsmeyer SJ; Nature 1995 Nov 30Cutaneous presentation of juvenile chronic myelogenous leukemia: a diagnostic and therapeutic dilemma.
Sires UI; Mallory SB; Hess JL; Keating JP; Bloomberg G; Dehner LP; Pediatric dermatology 1995 DecPeripheral T-cell lymphoma in lckpr-bcl-2 transgenic mice.
Linette GP; Hess JL; Sentman CL; Korsmeyer SJ; Blood 1995 Aug 15Causes of decreased phase transition temperature in selenite cataract model.
Mitton KP; Hess JL; Bunce GE; Investigative ophthalmology & visual science 1995 AprHistopathologic grading of nodular sclerosis Hodgkin's disease. Lack of prognostic significance in 254 surgically staged patients.
Hess JL; Bodis S; Pinkus G; Silver B; Mauch P; Cancer 1994 Jul 15Selenite and Ca2+ homeostasis in the rat lens: effect on Ca-ATPase and passive Ca2+ transport.
Wang Z; Bunce GE; Hess JL; Current eye research 1993 MarIntermediate lymphocytic lymphoma: clinical and pathologic features of a recently characterized subtype of non-Hodgkin's lymphoma.
Shivdasani RA; Hess JL; Skarin AT; Pinkus GS; Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1993 AprPhotosynthetic inhibition and superoxide dismutase activity in soybean cultivars exposed to short-term ozone fumigations.
Sheng WS; Chevone BI; Hess JL; Environmental pollution (Barking, Essex : 1987) 1993Purification of Multiple Forms of Glutathione Reductase from Pea (Pisum sativum L.) Seedlings and Enzyme Levels in Ozone-Fumigated Pea Leaves.
Madamanchi NR; Anderson JV; Alscher RG; Cramer CL; Hess JL; Plant physiology 1992 SepBiochemical changes and cataract formation in lenses from rats receiving multiple, low doses of sodium selenite.
Huang LL; Zhang CY; Hess JL; Bunce GE; Experimental eye research 1992 NovCalcium efflux in rat lens: Na/Ca-exchange related to cataract induced by selenite.
Wang Z; Hess JL; Bunce GE; Current eye research 1992 JulDeferoxamine effect on selenite-induced cataract formation in rats.
Wang Z; Hess JL; Bunce GE; Investigative ophthalmology & visual science 1992 JulSeasonal variation in the antioxidant system of eastern white pine needles : evidence for thermal dependence.
Anderson JV; Chevone BI; Hess JL; Plant physiology 1992 FebLens GSH depletion and electrolyte changes preceding cataracts induced by buthionine sulfoximine in suckling mice.
Calvin HI; von Hagen S; Hess JL; Patel SA; Fu SC; Experimental eye research 1992 AprRapid deterioration of lens fibers in GSH-depleted mouse pups.
Calvin HI; Medvedovsky C; David JC; Broglio TM; Hess JL; Fu SC; Worgul BV; Investigative ophthalmology & visual science 1991 MayPurification, characterization, and immunological properties for two isoforms of glutathione reductase from eastern white pine needles.
Anderson JV; Hess JL; Chevone BI; Plant physiology 1990 NovDNA damage, repair, and replication in selenite-induced cataract in rat lens.
Huang LL; Hess JL; Bunce GE; Current eye research 1990 NovRegulation of the visna virus long terminal repeat in macrophages involves cellular factors that bind sequences containing AP-1 sites.
Gabuzda DH; Hess JL; Small JA; Clements JE; Molecular and cellular biology 1989 JunSequences in the visna virus long terminal repeat that control transcriptional activity and respond to viral trans-activation: involvement of AP-1 sites in basal activity and trans-activation.
Hess JL; Small JA; Clements JE; Journal of virology 1989 JulIntracellular Localization of the Neurotoxin 2,4-Diaminobutyric Acid in Lathyrus sylvestris L. Leaf Tissue.
Foster JG; Cress WD; Wright SF; Hess JL; Plant physiology 1987 AprImmune responses in the central nervous system.
Griffin DE; Hess JL; Moench TR; Toxicologic pathology 1987Nucleotide sequence and transcriptional activity of the caprine arthritis-encephalitis virus long terminal repeat.
Hess JL; Pyper JM; Clements JE; Journal of virology 1986 NovCells with natural killer activity in the cerebrospinal fluid of normal mice and athymic nude mice with acute Sindbis virus encephalitis.
Griffin DE; Hess JL; Journal of immunology (Baltimore, Md. : 1950) 1986 Mar 1cis- and trans-acting transcriptional regulation of visna virus.
Hess JL; Clements JE; Narayan O; Science (New York, N.Y.) 1985 Aug 2Cataract formation following limited amino acid intake during gestation and lactation.
Bunce GE; Hess JL; Davis D; Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1984 SepGastrointestinal lesions in lambs due to multiple low-level blast overpressure exposure.
Clifford CB; Jaeger JJ; Moe JB; Hess JL; Military medicine 1984 SepLens calcium and selenite-induced cataract.
Bunce GE; Hess JL; Batra R; Current eye research 1984 FebExercise-thermoregulatory stress and increased plasma beta-endorphin/beta-lipotropin in humans.
Kelso TB; Herbert WG; Gwazdauskas FC; Goss FL; Hess JL; Journal of applied physiology: respiratory, environmental and exercise physiology 1984 AugImmunochemical features of a case of progressive rubella panencephalitis.
Wolinsky JS; Waxham MN; Hess JL; Townsend JJ; Baringer JR; Clinical and experimental immunology 1982 MayBiochemical changes associated with selenite-induced cataract in the rat.
Bunce GE; Hess JL; Experimental eye research 1981 NovAlkylation of rat lens crystallins with iodoacetamide.
Hess JL; Haynes LR; Bunce GE; Experimental eye research 1981 MarResponses of superoxide dismutase and glutathione reductase activities in cotton leaf tissue exposed to an atmosphere enriched in oxygen.
Foster JG; Hess JL; Plant physiology 1980 SepMMPI factor scale differences among heroin addicts differing in race and admission status.
Penk WE; Robinowitz R; Woodward WA; Hess JL; The International journal of the addictions 1980 AprUse of a simultaneous ligating-dividing-stapling instrument for ovariohysterectomy.
Hess JL; Veterinary medicine, small animal clinician : VM, SAC 1979 OctClinical utilization of mechanical sutures for intestinal anastomosis in Macaca mulatta.
Hess JL; Raflo CP; Laboratory animal science 1979 JunDifferences in MMPI scores of black and white compulsive heroin users.
Penk WE; Woodward WA; Rbinowitz R; Hess JL; Journal of abnormal psychology 1978 OctInvestigation of low tryptophan induced cataract in weanling rats.
Bunce GE; Hess JL; Fillnow GM; Experimental eye research 1978 AprQuantitative determination of alpha-tocopherol on thin layers of silica gel.
Hess JL; Pallansch MA; Harich K; Bunce GE; Analytical biochemistry 1977 DecLenticular opacities in young rats as a consequence of maternal diets low in tryptopham and/or vitamin E.
Bunce GE; Hess JL; The Journal of nutrition 1976 FebPartial purification and characterization of aspartate aminotransferases from seedling oat leaves.
Reed RE; Hess JL; The Journal of biological chemistry 1975 Jun 25A simple surgical treatment for acute periodontitis in the dog.
Love JW; Hess JL; Veterinary medicine, small animal clinician : VM, SAC 1975 JulUlcerative stomatitis in the python.
Hess JL; Rudy RL; Veterinary medicine, small animal clinician : VM, SAC 1974 NovConsiderations of oxalacetic acid keto--enol equilibria in various solvents.
Hess JL; Reed RE; Archives of biochemistry and biophysics 1972 NovGlycolate stimulation of oxygen evolution during photosynthesis.
Nelson EB; Tolbert NE; Hess JL; Plant physiology 1969 JanPlasma corticosterone levels as a function of cross-species fostering and species differences.
Denenberg VH; Rosenberg KM; Paschke R; Hess JL; Zarrow MX; Endocrinology 1968 OctStudies on chloroplast membrane structure. I. Association of pigments with chloroplast lamellar protein.
Ji TH; Hess JL; Benson AA; Biochimica et biophysica acta 1968 Jun 11Glycolate biosynthesis by Scenedesmus and Chlorella in the presence or absence of NaHCO3.
Hess JL; Tolbert NE; Pike LM; Planta 1967 SepGlycolate pathway in algae.
Hess JL; Tolbert NE; Plant physiology 1967 MarChanges in Chlorophyll a/b Ratio and Products of CO(2) Fixation by Algae Grown in Blue or Red Light.
Hess JL; Tolbert NE; Plant physiology 1967 AugThe effect of hydroxymethanesulfonates on 14-CO-2 photosynthesis by algae.
Tolbert NE; Hess JL; The Journal of biological chemistry 1966 Dec 10Glycolate, glycine, serine, and glycerate formation during photosynthesis by tobacco leaves.
Hess JL; Tolbert NE; The Journal of biological chemistry 1966 Dec 10SUPPLEMENTARY REPORT: INFLUENCE OF INTER-ITEM ASSOCIATIVE STRENGTH UPON IMMEDIATE FREE RECALL IN CHILDREN.
SIMON S; HESS JL; Psychological reports 1965 AprTheoretical investigations of dynamic response of man to high vertical accelerations.
HESS JL; LOMBARD CF; The Journal of aviation medicine 1958 Jan
Professional OrganizationsAlpha Omega Alpha Honor Medical SocietyAmerican Medical AssociationAmerican Society for Clinical InvestigationAssociation of American Medical Colleges Council of Deans Administrative Board
Board CertificationsPathologyAmerican Board of Pathology - Hematopathology
AwardsOrg: Indiana University
Desc: President's Medal
Org: The American Society for Clinical Investigation
Desc: Elected Member