Renzhi Han, PhD
Professor of Pediatrics
Bio
Dr. Han obtained his B.Sc. from Peking University and Ph.D. from the University of Western Australia, followed by postdoctoral training with Dr. Kevin P. Campbell at Howard Hughes Medical Institute, the University of Iowa. Dr. Han's research primarily focuses on studying genetic myopathies and developing adeno-associated viral (AAV) vectors and non-viral approaches for lasting correction of human diseases, such as muscular dystrophy and cardiovascular diseases. Dr. Han has served on a number of editorial boards and provided professional services to various funding agencies including NIH. He currently serves as an Associate Editor for Molecular Therapy.
Key Publications
Li H, Wang P, Zhang C, Zuo Y, Zhou Y, Han R*. (2023) Defective BVES-mediated feedback control of cAMP in muscular dystrophy. Nature Communications 14: 1785.
Zuo Y, Zhang C, Zhou Y, Li H, Xiao W, Herzog RW, Xu J, Zhang J, Chen EY, Han R*. (2023) Liver-specific in vivo base editing of Angptl3 via AAV delivery efficiently lowers blood lipid levels in mice. Cell & Bioscience 13: 109.
Wang P, Li H, Zhu M, Han RY, Guo S, Han R*. (2022) Correction of DMD in human iPSC-derived cardiomyocytes by base editing-induced exon skipping. Molecular Therapy - Methods & Clinical Development 28: 40-50.
Li H, Wang P, Hsu E, Pinckard KM, Stanford KI and Han R*. (2022) Systemic AAV9.BVES Delivery Ameliorates Muscular Dystrophy in a Mouse Model of LGMDR25. Molecular Therapy doi: 10.1016/j.ymthe.2022.11.012.
Li H, Lin P-H, Pranav G, Li X, Zhao L, Zhou X, Li Z, Wei S, Xu L, Han R, Lu J, Tan T, Yang D-H, Chen Z-S, Pawlik TM, Merritt RE, Ma J (2021) MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer. Molecular Cancer 20: 118.
Xu L, Zhang C, Li H, Wang P, Gao Y, Mokadam NA, Ma J, Arnold WD, Han R*. (2021) Efficient precise in vivo base editing in adult dystrophic mice. Nature Communications 12(1): 3719.
Li H, Zhao L, Lau YS, Zhang C, Han R*. (2020) Genome-wide CRISPR screen identifies LGALS2 as an oxidative stress-responsive gene with an inhibitory function on colon tumor growth. Oncogene doi: 10.1038/s41388-020-01523-5.
Xu L#, Lau YS#, Gao Y#, Li H, Han R*. (2019) Life-long AAV-mediated CRISPR genome editing in dystrophic heart improves cardiomyopathy without causing serious lesions in mdx mice. Molecular Therapy 27: 1407-1414.
El Refaey M, Xu L, Gao Y, Canan BD, Adesanya TMA, Warner SC, Akagi K, Symer DE, Mohler PJ, Ma J, Janssen PML, Han R*. (2017) In Vivo Genome Editing Restores Dystrophin Expression and Cardiac Function in Dystrophic Mice. Circulation Research 121: 923-929.
Xu L, Zhao L, Gao Y, Xu J, Han R*. (2017) Empower multiplex cell and tissue-specific CRISPR-mediated gene manipulation with self-cleaving ribozymes and tRNA. Nucleic Acids Research 45: e28.
Xu L, Park KH, Zhao L, Xu J, El Refaey M, Gao Y, Zhu H, Ma J, Han R*. (2015) CRISPR-mediated Genome Editing Restores Dystrophin Expression and Function in mdx Mice. Molecular Therapy 24: 564-569.
Zuo Y, Zhang C, Zhou Y, Li H, Xiao W, Herzog RW, Xu J, Zhang J, Chen EY, Han R*. (2023) Liver-specific in vivo base editing of Angptl3 via AAV delivery efficiently lowers blood lipid levels in mice. Cell & Bioscience 13: 109.
Wang P, Li H, Zhu M, Han RY, Guo S, Han R*. (2022) Correction of DMD in human iPSC-derived cardiomyocytes by base editing-induced exon skipping. Molecular Therapy - Methods & Clinical Development 28: 40-50.
Li H, Wang P, Hsu E, Pinckard KM, Stanford KI and Han R*. (2022) Systemic AAV9.BVES Delivery Ameliorates Muscular Dystrophy in a Mouse Model of LGMDR25. Molecular Therapy doi: 10.1016/j.ymthe.2022.11.012.
Li H, Lin P-H, Pranav G, Li X, Zhao L, Zhou X, Li Z, Wei S, Xu L, Han R, Lu J, Tan T, Yang D-H, Chen Z-S, Pawlik TM, Merritt RE, Ma J (2021) MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer. Molecular Cancer 20: 118.
Xu L, Zhang C, Li H, Wang P, Gao Y, Mokadam NA, Ma J, Arnold WD, Han R*. (2021) Efficient precise in vivo base editing in adult dystrophic mice. Nature Communications 12(1): 3719.
Li H, Zhao L, Lau YS, Zhang C, Han R*. (2020) Genome-wide CRISPR screen identifies LGALS2 as an oxidative stress-responsive gene with an inhibitory function on colon tumor growth. Oncogene doi: 10.1038/s41388-020-01523-5.
Xu L#, Lau YS#, Gao Y#, Li H, Han R*. (2019) Life-long AAV-mediated CRISPR genome editing in dystrophic heart improves cardiomyopathy without causing serious lesions in mdx mice. Molecular Therapy 27: 1407-1414.
El Refaey M, Xu L, Gao Y, Canan BD, Adesanya TMA, Warner SC, Akagi K, Symer DE, Mohler PJ, Ma J, Janssen PML, Han R*. (2017) In Vivo Genome Editing Restores Dystrophin Expression and Cardiac Function in Dystrophic Mice. Circulation Research 121: 923-929.
Xu L, Zhao L, Gao Y, Xu J, Han R*. (2017) Empower multiplex cell and tissue-specific CRISPR-mediated gene manipulation with self-cleaving ribozymes and tRNA. Nucleic Acids Research 45: e28.
Xu L, Park KH, Zhao L, Xu J, El Refaey M, Gao Y, Zhu H, Ma J, Han R*. (2015) CRISPR-mediated Genome Editing Restores Dystrophin Expression and Function in mdx Mice. Molecular Therapy 24: 564-569.
Titles & Appointments
- Professor of Pediatrics
- Adjunct Professor of Medical & Molecular Genetics
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Education
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