Nicholas E. Harrison, MD, MSC

Dr. Harrison was born in Dearborn, Michigan and raised in the suburbs of Detroit. He graduated from Michigan State University (MSU) for both his undergraduate and medical school (MD) degrees, in 2008 and 2012, respectively. While at the MSU College of Human Medicine he spent two years at the Flint MI MSU Clinical Campus and two months living abroad in Peru, completeing the school's MD Leadership in Medicine for the Underserved certificate program.  He completed his residency training in Emergency Medicine at the Oakland University William Beaumont School of Medicine's / William Beaumont Hospital Emergency Medicine Program, where he served as Chief Resident in his final year.  

Upon completing residency in 2019, Dr. Harrison entered a two year Fellowship in Clinical Research, studying heart failure and cardiovascular imaging under the mentorship of Dr. Phillip Levy at Wayne State University.  He concurrently entered the Clinical Research Design and Statistical Analysis MSc program for clinician-scientists at the University of Michigan's Department of Biostatistics.  He graduated both his research fellowship and his MSc in 2021, at which time he took his first full time faculty position as a tenure-track Assistant Professor of Emergency Medicine at IUSM in Indianapolis.  

Dr. Harrison works clinically at IUH Methodist Hospital, while continuing the translational and health services research he began during his fellowship, in acute heart failure and non-invasive cardiovascular imaging.  Starting in 2022, and ending in 2024, he recieved a KL2 Career Development Award funded by the National Institutes of Health National Center for Advancing Translational Sciences (NIH NCATS) through the Indiana Clinical and Translational Sciences Institute.

As of 2023 he has been married for 10 years to his wife Ashley, an adult primary care nurse practitioner. They have two children, Abigail and Hannah.

*Updated as of June 2023.  Please see Pubmed for a complete list of works.

Reports of Original Work

1. Goldsmith A, Jin M, Lucassen R, Duggan N, Harrison NE, Wells W, Ehrman RE, Ferre R, Gargani L, Noble V, Levy P, Lane K, Li X, Collins SP, Kapur T, Pang P, Russell FM. Comparison of Pulmonary Congestion severity using AI-assisted scoring vs. clinical experts: A Secondary Analysis of BLUSHED-AHF. European J Heart Failure. 2023; 10.1002/ejhf.2881

 

2. Mathew S, Harrison NE, Ajimal S, Silvagi S, Reece R, Klausner H, Levy P, Dunne R, O’Neil B. Treatment and Outcome Variation in Out-of-hospital Cardiac Arrest Among Four Urban Hospitals in Detroit. Resuscitation. 2023 Feb 10; doi: https://doi.org/10.1016/j.resuscitation.2023.109731

 

3. Harrison NE, Koester J, Farmer A, Hannon A, Jakupko N, Nanagas J, Park S, Li X, Collins S, Monahan P, Pang P. Emergency Physician Risk-Tolerance in Acute Heart Failure is Higher than Previously Thought, and Compatible with Modern Disposition Decision Instruments. Acad Emerg Med. 2022; doi: 10.1111/ACEM.14641

 

4. Harrison NE, Favot M, Gowland L, Lenning J, Henry S, Gupta S, Abidov A, Welch R, Levy P, Ehrman R.  Point-of-care echocardiography of the right heart improves acute heart failure risk stratification for low-risk patients: The REED-AHF prospective study. Acad Emerg Med. 2022; 00: 1- 14. doi: 10.1111/acem.14589

 

5. Ehrman R, Bredell BX, Harrison NE, Favot M, Haber BD, Welch RW, Levy PD, Sherwin RL. Increasing illness severity is associated with global myocardial dysfunction in the first 24 hours of sepsis admission. Ultrasound J 14, 32 (2022). https://doi.org/10.1186/s13089-022-00282-6

 

6. Ehrman RR, Favot MJ, Harrison NE, Khait L, Ottenhoff JE, Welch RD, Levy PD, Sherwin RL. Early echocardiographic assessment of cardiac function may be prognostically informative in unresuscitated patients with sepsis: A prospective observational study. PLoS One. 2022 Jul 8;17(7):e0269814. doi: 10.1371/journal.pone.0269814. PMID: 35802886; PMCID: PMC9270056.

 

7. Harrison NE, Meram S, Li X, White MB, Henry S, Gupta S, Zhu D, Pang P, Levy P. Hemodynamic profiles by non-invasive monitoring of cardiac index and vascular tone in acute heart failure patients in the emergency department: External validation and clinical outcomes. PLoS One. 2022 Mar 31;17(3):e0265895. doi: 10.1371/journal.pone.0265895. PMID: 35358231; PMCID: PMC8970400.

 

8. Srivastava M, Harrison N, Caetano AFS, Tan AR, Law M. Ultrafiltration for acute heart failure. Cochrane Database Syst Rev. 2022 Jan 21;1(1):CD013593. doi: 10.1002/14651858.CD013593.pub2. PMID: 35061249; PMCID: PMC8781783.

 

9. Ehrman RR, Ottenhoff JD, Favot MJ, Harrison NE, Khait L, Welch RD, Levy PD, Sherwin RL. Do septic patients with reduced left ventricular ejection fraction require a low-volume resuscitative strategy? Am J Emerg Med. 2021 Dec 8;52:187-190. doi: 10.1016/j.ajem.2021.11.046. PMID: 34952322.

 

10. Harrison NE, Ehrman R, Favot M, Gowland L, Lenning J, Abidov A, Henry S, Gupta S, Welch R, Levy P. “Right Ventricular Dysfunction in Acute Heart Failure from Emergency Department to Discharge: Predictors and Clinical Implications.” American Journal of Emergency Medicine. 2021; doi:10.1016/j.ajem.2021.11.024. PMID: 34861517                                       

 

11. Harrison NE, Ehrman RR, Curtin A, Gorelick D, Hill AB, Brennan E, Dunne R.  “Factors Associated With Voluntary Refusal of Emergency Medical System Transport for Emergency Care in Detroit During the Early Phase of the COVID-19 Pandemic”. JAMA Netw Open. 2021;4(8):e2120728. doi:10.1001/jamanetworkopen.2021.20728

 

12. Mathew S, Harrison N, Chalek AD, Gorelick D, Brennan E, Wise S, Gandolfo L, O'Neil B, Dunne R. Effects of the COVID-19 pandemic on out-of-hospital cardiac arrest care in Detroit. Am J Emerg Med. 2021 Mar 11;46:90-96. doi: 10.1016/j.ajem.2021.03.025. PMID: 33740572; PMCID: PMC7946542.

 

13. Harrison N, Pang P, Collins S, Levy P. Blood Pressure Reduction in Hypertensive Acute Heart Failure. Current Hypertension Reports 2021, 23:11. DOI: 10.1007/s11906-021-01127-8

 

14. Favot M*, Malik A, Rowland J, Haber B, Ehrman R, Harrison N*. Point-of-Care Lung Ultrasound for Detecting Severe Presentations of Coronavirus Disease 2019 in the Emergency Department: A Retrospective Analysis. Critical Care Explorations. 2020;2(8):e0176.

            *Co-First Authors

 

15. Srivastava M, Harrison N, Caetano AFSMA, Tan AR, Law M. Ultrafiltration for acute heart failure (Protocol). Cochrane Database of Systematic Reviews 2020, Issue 4. Art. No.: CD013593. DOI: 10.1002/14651858.CD013593.

 

16. Ehrman RR, Gallien JZ, Smith RK, Akers KG, Malik AN, Harrison NE, Welch RD, Levy PD, Sherwin RL. Resuscitation Guided by Volume Responsiveness Does Not Reduce Mortality in Sepsis: A Meta-Analysis. Crit Care Explor. 2019 May 23;1(5):e0015. doi: 10.1097/CCE.0000000000000015. PMID: 32166259; PMCID: PMC7063966.

 

17. Wakai A, Lawrenson JG, Lawrenson AL, Wang Y, Brown MD, Quirke M, Ghandour O, McCormick R, Walsh CD, Amayem A, Lang E, Harrison N. Topical non-steroidal anti-inflammatory drugs for analgesia in traumatic corneal abrasions. Cochrane Database Syst Rev. 2017 May 18;5:CD009781. doi: 10.1002/14651858.CD009781.pub2.

 

18. Harrison, N, B Cavinder, JP Townsend, and F Trail (2013) "Optimized primers and other critical conditions for efficient fusion PCR to generate knockout vectors in filamentous fungi.," Fungal Genetics Reports: Vol. 60, Article 1. https://doi.org/10.4148/1941-4765.1006

 

 

Case Reports

19. Maloy J, Harrison N, Bahl A. Acute Respiratory Distress. Clin Pract Cases Emerg Med. 2018;2(3):272-273. Published 2018 Jul 16. doi:10.5811/cpcem.2018.5.38041

 

 

Review Articles

20. Harrison N, Favot M, Levy P. The Role of Troponin for Acute Heart Failure. Curr Heart Fail Rep. 2019 Feb;16(1):21-31. doi: 10.1007/s11897-019-0420-5. PMID: 30762176.

 

21. Harrison N, Babcock C. Are α-Blockers Beneficial for Outpatient Management of Uncomplicated Ureteric Stones? Ann Emerg Med. 2018 Jan;71(1):138-140. doi: 10.1016/j.annemergmed.2017.04.001. Epub 2017 May 27. PMID: 28559040.

 

22. Harrison NE, Gottlieb M. Comparison of Fresh Frozen Plasma With Prothrombin Complex Concentrate for Warfarin Reversal. Ann Emerg Med. 2017 Jun;69(6):777-779. doi: 10.1016/j.annemergmed.2016.10.028. Epub 2017 Jan 19. PMID: 28110988.

 

Editorials/Commentaries

 

23. Paxton JH, Messman AM, Harrison NE, Malik AN, Burke RJ, Levy PD. Resident Research in Emergency Medicine: An Introduction and Primer. West J Emerg Med. 2020 Aug 24;21(5):1118-1122. doi: 10.5811/westjem.2020.6.46520. PMID: 32970564; PMCID: PMC7514385.

 

Letters to the Editor

24. Ehrman RR, Collins J, Harrison N. Prevalence of Pulmonary Embolism in Emergency Department Patients With Suspected COVID-19: The Truth Remains Unknown. Acad Emerg Med. 2020 Nov;27(11):1216-1217. doi: 10.1111/acem.14137. Epub 2020 Oct 16. PMID: 32969120; PMCID: PMC7537082.

 

Book Authorships, Editorships, and Chapters

 

25. Harrison NE, Levy PD. Heart Failure. In: Walls RM, editor. Rosen’s Emergency Medicine: Concepts and Clinical Practice. 10th ed. Philadelphia, PA: Elsevier; 2022. p. 934-54.

 

Peer-Reviewed Manuscripts of Clinical Guidelines/Policies Listed in Pubmed

26. Diercks D, Adkins E, Harrison NE, Sokolove P, Kwok H, Wolf S. “Clinical Policy: Critical Issues in the Evaluation and Management of Emergency Department Patients with Suspected Appendicitis.” Annals of Emergency Medicine, Volume 81, Issue 6, e115 - e152

 

28. Expert Panel on Vascular Imaging, Verma N; Steigner ML; Aghayev A; Azene EM; Chong ST; Desjardins, MD; El Khouli RH; Harrison NE; Hedgire SS; Kalva SP; Lee Y; Mauro M; Mehta HJ; Meissner M; Pillai AK; Singh N; Suranyi PS; Williamson EE; Dill KE. ACR Appropriateness Criteria® Retroperitoneal Bleed. J Am Coll Radiol. 2021 Nov; 18(11S):S482-487. doi:10.1016/j.jacr.2021.09.003. PMID: 34794602.

 

29. Olsen KM, Manouchehr-pour S, Donnelly EF, Henry TS, Berry MF, Boiselle PM, Colletti PM, Harrison NE, Kuzniewski CT, Laroia AT, Maldonado F, Pinchot JW, Raptis CA, Shim K, Tong BC, Wu CC, Kanne JP. ACR Appropriateness Criteria: Hemoptysis. American College of Radiology. Journal of the American College of Radiology, May 2020 Supplement. doi: 10.1016/j.jacr.2020.01.043

 

30. Godwin SA, Cherkas DS, Panagos PD, Shih RD, Byyny R, Wolf SJ, Carpenter CR, Diercks DB, Gemme SR, Gerardo CJ, Godwin SA, Hahn SA, Harrison NE*, Hatten BW, Haukoos JS, Kaji A, Kwok H, Lo BM, Mace SE, Nazarian DJ, Proehl J, Promes SB, Shah KH, Silvers SM, Smith MD, Thiessen ME, Tomaszewski CA, Valente JH, Wall SP, Cantrill SV, Hirshon JM, Schulz J, Whitson RR.

Clinical Policy: Critical Issues in the Evaluation and Management of Adult Patients Presenting to the Emergency Department With Acute Headache. Annals of Emergency Medicine. 2019; 74: 4. doi: 10.1016/j.annemergmed.2019.07.009.

            *Collaborator

 

31. Tomaszewski CA, Nestler D, Shah KH, Sudhir A, Brown, MD, Wolf SJ, Byyny R, Diercks DB, Gemme SR, Gerardo CJ, Godwin SA, Hahn SA, Harrison NE*, Hatten BW, Haukoos JS, Kaji A, Kwok H, Lo BM, Mace SE, Nazarian DJ, Proehl J, Promes SB, Shih RD, Silvers SM, Smith MD, Thiessen ME, Valente JH, Wall SP, Cantrill SV, Hirshon JM, Schulz J, Whitson RR. Clinical Policy: Critical Issues in the Evaluation and Management of Emergency Department Patients With Suspected Non–ST-Elevation Acute Coronary Syndromes. Annals of Emergency Medicine. 2018; 72:5. doi: 10.1016/j.annemergmed.2018.07.045

            *Collaborator