1994 FEL Postdoctoral Fellowship, Mayo Clinic, Rochester, MN

1991 FEL Postdoctoral Fellowship, Albert Einstein Yeshiva University

1988 FEL Postdoctoral Fellowship, Mount Sinai Medical Center, New York, NY

1985 PhD Sapienza Università di Roma

My research program focuses on the regulation of cholangiocyte proliferation/damage during cholangiopathies. My studies have demonstrated the key role of a number of factors such as vascular and nerve factors, melatonin, secretin, biogenic amines and sex hormones (expressed and secreted by cholangiocytes) in the regulation of biliary growth/damage by autocrine/paracrine mechanisms.  Proliferating cholangiocytes display a neuroendocrine phenotype and secrete and respond to a number of hormones, neuropeptides and neurotransmitters in autocrine and paracrine signaling mechanisms.  My research interests also include determining the interactions that occur between cholangiocytes and other cell types (such as hepatocytes, hepatic stellate cells, and vascular endothelial cells) in the biliary microenvironment during both cholestasis and cholangiocarcinogenesis.  My program evaluates the various signaling mechanisms regulating the balance between biliary growth/damage. 

I have expertise in the areas of factors that regulate hepatic/cell mitosis and apoptosis in particular the regulation of the balance of proliferation and apoptosis by bile acids, neurotransmitters, gastrointestinal hormones, and angiogenic factors.  In addition, I have expertise in epithelial transport mechanisms.   I have also expertise in the regulation of non-coding RNA (ncRNA) expressions, including microRNA and transcribed ultra-conserved regions (T-UCRs), in hepatobiliary cancers and stem cells.  In particular, how aberrant ncRNA expression contributes to the evasiveness of the cancer stem cells and resistance to chemotherapy.

Indole Supplementation Ameliorates MCD-induced NASH in mice.
Zhu B; Li H; Lu B; Guo X; Wu C; Wang F; Li Q; Xie L; Glaser S; Francis H; Alpini G; Wu C; The Journal of nutritional biochemistry 2022 May 11

The challenges of primary biliary cholangitis: What is new and what needs to be done.
Terziroli Beretta-Piccoli B; Mieli-Vergani G; Vergani D; Vierling JM; Adams D; Alpini G; Banales JM; Beuers U; Björnsson E; Bowlus C; Carbone M; Chazouillères O; Dalekos G; De Gottardi A; Harada K; Hirschfield G; Invernizzi P; Jones D; Krawitt E; Lanzavecchia A; Lian ZX; Ma X; Manns M; Mavilio D; Quigley EM; Sallusto F; Shimoda S; Strazzabosco M; Swain M; Tanaka A; Trauner M; Tsuneyama K; Zigmond E; Gershwin ME; Journal of autoimmunity 2019 Sep 20

Downregulation of hepatic stem cell factor by Vivo-Morpholino treatment inhibits mast cell migration and decreases biliary damage/senescence and liver fibrosis in Mdr2^-/- mice.
Meadows V; Kennedy L; Hargrove L; Demieville J; Meng F; Virani S; Reinhart E; Kyritsi K; Invernizzi P; Yang Z; Wu N; Liangpunsakul S; Alpini G; Francis H; Biochimica et biophysica acta. Molecular basis of disease 2019 Sep 13

Knockdown of vimentin reduces mesenchymal phenotype of cholangiocytes in the Mdr2^-/- mouse model of primary sclerosing cholangitis (PSC).
Zhou T; Kyritsi K; Wu N; Francis H; Yang Z; Chen L; O'Brien A; Kennedy L; Ceci L; Meadows V; Kusumanchi P; Wu C; Baiocchi L; Skill NJ; Saxena R; Sybenga A; Xie L; Liangpunsakul S; Meng F; Alpini G; Glaser S; EBioMedicine 2019 Sep 12

Possible application of melatonin treatment in human diseases of the biliary tract.
Baiocchi L; Zhou T; Liangpunsakul S; Ilaria L; Milana M; Meng F; Kennedy L; Kusumanchi P; Yang Z; Ceci L; Glaser S; Francis H; Alpini G; American journal of physiology. Gastrointestinal and liver physiology 2019 Sep 11

Role of Non-Coding RNAs in the Progression of Liver Cancer: Evidence from Experimental Models.
O'Brien A; Zhou T; Tan C; Alpini G; Glaser S; Cancers 2019 Oct 25

Maternal diet intervention before pregnancy primes offspring lipid metabolism in liver.
Zhou Y; Peng H; Xu H; Li J; Golovko M; Cheng H; Lynch EC; Liu L; McCauley N; Kennedy L; Alpini G; Zhang KK; Xie L; Laboratory investigation; a journal of technical methods and pathology 2019 Nov 20

Intercellular Communication between Hepatic Cells in Liver Diseases.
Sato K; Kennedy L; Liangpunsakul S; Kusumanchi P; Yang Z; Meng F; Glaser S; Francis H; Alpini G; International journal of molecular sciences 2019 May 2

Pinealectomy or light exposure exacerbates biliary damage and liver fibrosis in cholestatic rats through decreased melatonin synthesis.
Chen L; Zhou T; Wu N; O'Brien A; Venter J; Ceci L; Kyritsi K; Onori P; Gaudio E; Sybenga A; Xie L; Wu C; Fabris L; Invernizzi P; Zawieja D; Liangpunsakul S; Meng F; Francis H; Alpini G; Huang Q; Glaser S; Biochimica et biophysica acta. Molecular basis of disease 2019 Mar 16

Secretin/secretin receptor signaling mediates biliary damage and liver fibrosis in early-stage primary biliary cholangitis.
Kennedy L; Francis H; Invernizzi P; Venter J; Wu N; Carbone M; Gershwin ME; Bernuzzi F; Franchitto A; Alvaro D; Marzioni M; Onori P; Gaudio E; Sybenga A; Fabris L; Meng F; Glaser S; Alpini G; FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jun 28

Fructose Promotion of Intestinal and Liver Injury: A Sugar by Any Other Name That Isn't So Sweet.
Kennedy L; Francis H; Alpini G; Hepatology (Baltimore, Md.) 2019 Jul 5

Modulation of the Tryptophan Hydroxylase 1/Monoamine Oxidase-A/5-Hydroxytryptamine/5-Hydroxytryptamine Receptor 2A/2B/2C Axis Regulates Biliary Proliferation and Liver Fibrosis During Cholestasis.
Kyritsi K; Chen L; O'Brien A; Francis H; Hein TW; Venter J; Wu N; Ceci L; Zhou T; Zawieja D; Gashev AA; Meng F; Invernizzi P; Fabris L; Wu C; Skill NJ; Saxena R; Liangpunsakul S; Alpini G; Glaser SS; Hepatology (Baltimore, Md.) 2019 Jul 25

Antitumor Activity of a Novel Fibroblast Growth Factor Receptor Inhibitor for Intrahepatic Cholangiocarcinoma.
Raggi C; Fiaccadori K; Pastore M; Correnti M; Piombanti B; Forti E; Navari N; Abbadessa G; Hall T; Destro A; Di Tommaso L; Roncalli M; Meng F; Glaser S; Rovida E; Peraldo-Neia C; Olaizola P; Banales JM; Gerussi A; Elvevi A; Droz Dit Busset M; Bhoori S; Mazzaferro V; Alpini G; Marra F; Invernizzi P; The American journal of pathology 2019 Jul 24

Knockout of a-calcitonin gene-related peptide attenuates cholestatic liver injury by differentially regulating cellular senescence of hepatic stellate cells and cholangiocytes.
Wan Y; Ceci L; Wu N; Zhou T; Chen L; Venter J; Francis H; Bernuzzi F; Invernizzi P; Kyritsi K; Baker P; Huang Q; Wu C; Sybenga A; Alpini G; Meng F; Glaser S; Laboratory investigation; a journal of technical methods and pathology 2019 Jan 30

Hepatocyte-specific and extra-hepatocyte actions of perilipin-2 during fatty liver disease: benefits of being extra.
Kennedy L; Francis H; Alpini G; The Journal of physiology 2019 Jan 29

FXR deficiency and alcoholic liver disease: Tissue is the issue.
Alpini G; Tariq R; Singal AK; Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2019 Feb 7

Reply.
Sato K; Meng F; Alpini G; Hepatology (Baltimore, Md.) 2019 Aug

Hepatitis C Virus Infection and Cholangiocarcinoma: An Insight into Epidemiologic Evidences and Hypothetical Mechanisms of Oncogenesis.
Navas MC; Glaser S; Dhruv H; Celinski S; Alpini G; Meng F; The American journal of pathology 2019 Apr 4

Sphingosine lipid signaling in alcoholic liver injury.
Alpini G; Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2019 Apr 25

Preclinical insights into cholangiopathies: disease modeling and emerging therapeutic targets.
Sato K; Glaser S; Kennedy L; Liangpunsakul S; Meng F; Francis H; Alpini G; Expert opinion on therapeutic targets 2019 Apr 22

Dual Role of Bile Acids on the Biliary Epithelium: Friend or Foe?
Baiocchi L; Zhou T; Liangpunsakul S; Lenci I; Santopaolo F; Meng F; Kennedy L; Glaser S; Francis H; Alpini G; International journal of molecular sciences 2019 Apr 16

Amelioration of Ductular Reaction by Stem Cell Derived Extracellular Vesicles in MDR2 Knockout Mice via Lethal-7 microRNA.
McDaniel K; Wu N; Zhou T; Huang L; Sato K; Venter J; Ceci L; Chen D; Ramos-Lorenzo S; Invernizzi P; Bernuzzi F; Wu C; Francis H; Glaser S; Alpini G; Meng F; Hepatology (Baltimore, Md.) 2019 Apr 12

Prolonged intake of desloratadine: mesenteric lymphatic vessel dysfunction and development of obesity/metabolic syndrome.
Gasheva OY; Tsoy Nizamutdinova I; Hargrove L; Gobbell C; Troyanova-Wood M; Alpini SF; Pal S; Du C; Hitt AR; Yakovlev VV; Newell-Rogers MK; Zawieja DC; Meininger CJ; Alpini GD; Francis H; Gashev AA; American journal of physiology. Gastrointestinal and liver physiology 2018 Nov 26

Ductular Reaction in Liver Diseases: Pathological Mechanisms and Translational Significances.
Sato K; Marzioni M; Meng F; Francis H; Glaser S; Alpini G; Hepatology (Baltimore, Md.) 2018 Dec 27

Hepatocyte and stellate cell deletion of liver fatty acid binding protein reveals distinct roles in fibrogenic injury.
Newberry EP; Xie Y; Lodeiro C; Solis R; Moritz W; Kennedy S; Barron L; Onufer E; Alpini G; Zhou T; Blaner WS; Chen A; Davidson NO; FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Dec 21

American Association for Study of Liver Diseases

American Gastroenterological Association

American Physiological Society

American Society for Biochemistry and Molecular Biology

American Society for Investigative Pathology

American Society of Cell Biology

European Association for the Study of the Liver

Experimental Biology and Medicine

Org: American Physiological Society
Desc: Takeda Award, Gastrointestinal & Liver Section
Scope: National
Date:

Org: American Association for the Study of Liver Diseases
Desc: Fellow
Scope: National
Date:

Org: American Gastroenterology Association
Desc: Fellow
Scope: National
Date:

Org: Association of Military Surgeons of the United States
Desc: Research and Development Award
Scope: National
Date: