42064-Wu, Wenting

Wenting Wu, PhD

Assistant Research Professor of Medical & Molecular Genetics

MS 2031
Indianapolis, IN


Dr.Wu obtained her PhD from Fudan University and subsequently completed postdoctoral training in human genetics, genetic epidemiology and bioinformatics at University of California, San Diego and Indiana University.  Dr.Wu is utilizing integrative approach, combining computational, comparative, and functional genomic methods to investigate the genomics and transcription regulation of complex disease mechanism and personalizing medicine. She has published 70 original research articles in peer-reviewed journals, with a total of > 3,809 citations (Google scholar, H-index = 28).

Key Publications

Full list of publications can be accessed at Google Scholar https://scholar.google.com/citations?hl=en&user=1dF9-s0AAAAJ&view_op=list_works&sortby=pubdate

Selected publications

  1. Wu W, Syed F, Simpson E, Lee C, Liu J, Chang G, Dong C, Seitz C, L. Eizirik D, G. Mirmira R, Liu Y, Evans-Molina C: The Impact of Pro-Inflammatory Cytokines on Alternative Splicing Patterns in Human Islets. Diabetes 2021;71:116-127.(Cover Image)
  2. Kusmartseva I*, Wu W*, Syed F*, Van Der Heide V*, Jorgensen M*, Joseph P, Tang X, Candelario-Jalil E, Yang C, Nick H, et al. Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19. Cell Metabolism 2020, 32 (6) :1041-1051.e6 (Co-first author).
  3. Anderson-Baucum E, Piñeros AR, Kulkarni A, Webb-Robertson BJ, Maier B, Anderson RM, Wu W, Tersey SA, Mastracci TL, Casimiro I, Scheuner D, Metz TO, Nakayasu ES, Evans-Molina C, Mirmira RG. Deoxyhypusine synthase promotes a pro-inflammatory macrophage phenotype. Cell Metabolism. 2021 Sep 7;33(9):1883-1893.
  4. Piñeros AR, Gao H, Wu W, Liu Y, Tersey SA, Mirmira RG: Single-Cell Transcriptional Profiling of Mouse Islets Following Short-Term Obesogenic Dietary Intervention. Metabolites 2020;10:513
  5. Visconti A, Duffy D, Liu F, Zhu G, Wu WCheng Y, Hysi P, Zeng C, Sanna M, Iles M, et alGenome-wide association study in 176,678 Europeans reveals new genetic loci for tanning response to sun exposure. Nature Communications 20189(1):1684.
  6. Zhang T, Choi J, Kovacs MA, Shi J, Xu M, NISC Comparative Sequencing Program, …, Wu W, et al. Cell-type-specific eQTL of primary melanocytes facilitates identification of melanoma susceptibility genes. Genome Research2018,11: 1621-1635.
  7. Marshall C, Howrigan D, Merico D, Thiruvahindrapuram B, Wu W† (5th out of 268 coauthors), Scherer S, Neale B, Sebat J, on behalf of the Schizophrenia and CNV analysis groups of the Psychiatric Genomics Consortium: Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects. Nature Genetics 2017, 49, 27–35. († One of the lead authors).
  8. Chahal HS*, Wu W*, Ransohoff KJ, Yang L, Hedlin H, Desai M, Lin Y, Dai H-J, Qureshi AA, Li W-Q et al: Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma.  Nature Communications2016, 7:12510. (Co-first author).
  9. Wu W, Wagner EK, Hao Y, Rao X, Dai H, Han J, Chen J, Storniolo AMV, Liu Y, He C: Tissue-specific Co-expression of Long Non-coding and Coding RNAs Associated with Breast Cancer. Scientific Reports2016, 6:32731.
  10. Michaelson JJ, Shi Y, Gujral M, Zheng H, Malhotra D, Jin X, Jian M, Liu G, Greer D, Bhandari A, Wu W, et al: Whole-Genome Sequencing in Autism Identifies Hot Spots for De Novo Germline Mutation. Cell, 2012, 151(7): 1431-1442.
  11. Wang H*, Wu W*, Wang H, Wang S, Chen Y, Zhang X, Yang J, Zhao S, Ding H, Lu D: Analysis of specialized DNA polymerases expression in human gliomas: association with prognostic significance. Neuro-Oncology2010, 12(7): 679-686. (Co-first author).
  12. Wu W, Zhang W, Qiao R, Chen D, Wang H, Wang Y, Zhang S, Gao G, Gu A, Shen J et al: Association of XPD Polymorphisms with Severe Toxicity in Non-Small Cell Lung Cancer Patients in a Chinese Population. Clinical Cancer Research, 2009, 15(11): 3889-3895.

Titles & Appointments

  • Assistant Research Professor of Medical & Molecular Genetics
  • Education
    2010 PhD Fudan University
    2005 BS Wuhan University
  • Research

    Dr.Wu has been focusing on characterizing the role of genomic variation/mutations/structural variation, methylation, mRNAs, long non-coding RNAs in complex disease, to uncover the underlying biological mechanism for human disease. The goal of her current research is to investigate the genomics and transcription regulation of Type 1, 2 Diabetes disease. Recently, she has been working on studying dynamics of transcription regulation, pre-mRNA splicing regulation in human islets treated with pro-inflammatory cytokines and relating these regulation events to those appearing in the circulation of subjects with new-onset Type 1 Diabetes.  Her future research interests including: 1) integrating single cell sequencing signatures with existing bulk RNA sequencing data to better assess cell-specific gene expression changes; 2) uncovering the genomics mechanism and functional significance of disease-associated loci 3) translating genomics into therapeutics and diagnostics methodology for the purpose of precision medicine.

  • Professional Organizations
    American Diabetes Association
    American Society of Human Genetics
  • Awards
    Org: NIDDK dkNET New Investigator Pilot Program in Bioinformatics, NIH
    Scope: National
    Date: 2022-06-16
    Org: Center for Diabetes and Metabolic Disease, Pilot & Feasibility Awards, NIH
    Scope: National
    Date: 2019-08-16

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