41977-Kim, Jungsu

Jungsu Kim, PhD

P. Michael Conneally Professor of Medical and Molecular Genetics

NB 108B

Indianapolis, IN
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Dr. Kim is the P. Michael Conneally Professor of Medical and Molecular Genetics. Dr. Kim graduated Summa Cum Laude in 2000 from Pohang University of Science & Technology in Korea with a bachelor’s degree in life science. He earned his Ph.D. from Mayo Clinic College of Medicine in 2007 under the guidance of Dr. Todd Golde and completed his postdoctoral training at Washington University in the laboratory of Dr. David Holtzman. After 3 years of postdoctoral training, he established his laboratory at Washington University, as an Assistant Professor in the Department of Neurology. In June 2013, Dr. Kim joined the Department of Neuroscience at Mayo Clinic. After 5 years of tenure as a Senior Associate Consultant I at Mayo Clinic, Dr. Kim relocated his laboratory to the Stark Neurosciences Research Institute at IU School of Medicine in 2018.

Key Publications

  1. Kim, B., et al. Effects of SPI1-mediated transcriptome remodeling on Alzheimer’s disease-related phenotypes in mouse models of Aβ amyloidosis. Nat. Commun. 15, 3996 (2024).
  2. Tate, M.D., Karahan, H. & Kim, J. APOE loss of function: A genetic shield against Alzheimer’s disease. Neuron 112, 1033-1035 (2024).
  3. Acri, D.J., et al. Network analysis identifies strain-dependent response to tau and tau seeding-associated genes. J. Exp. Med. 220(2023).
  4. Karahan, H., et al. Deletion of Abi3 gene locus exacerbates neuropathological features of Alzheimer's disease in a mouse model of Abeta amyloidosis. Science Advances 7, eabe3954 (2021).
  5. Karahan, H., Dabin, L.C., Tate, M.D. & Kim, J. MicroRNAs on the move: microRNAs in astrocyte-derived ApoE particles regulate neuronal function. Neuron 109, 907-909 (2021).
  6. Liao, F., Yoon, H. & Kim, J. Apolipoprotein E metabolism and functions in brain and its role in Alzheimer's disease. Curr. Opin. Lipidol. 28, 60-67 (2017).
  7. Yoon, H., Flores, L.F. & Kim, J. MicroRNAs in brain cholesterol metabolism and their implications for Alzheimer's disease. Biochim. Biophys. Acta 1861, 2139-2147 (2016).
  8. Kim, J., et al. miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1). Mol. Neurodegener. 11, 55 (2016).
  9. Kim, J., et al. microRNA-33 Regulates ApoE Lipidation and Amyloid-beta Metabolism in the Brain. J. Neurosci. 35, 14717-14726 (2015).
  10. Choi, J., et al. The E3 ubiquitin ligase Idol controls brain LDL receptor expression, ApoE clearance, and Abeta amyloidosis. Sci. Transl. Med. 7, 314ra184 (2015).
  11. Kim, J., et al. Normal cognition in transgenic BRI2-Abeta mice. Mol. Neurodegener. 8, 15 (2013).
  12. Kim, J., et al. miR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression. Exp. Neurol. 235, 476-483 (2012).
  13. Kim, J., et al. Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Abeta amyloidosis. J. Exp. Med. 209, 2149-2156 (2012).
  14. Basak, J.M., et al. Measurement of apolipoprotein E and amyloid beta clearance rates in the mouse brain using bolus stable isotope labeling. Mol. Neurodegener. 7, 14 (2012).
  15. Kim, J., et al. Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-beta amyloidosis. J. Neurosci. 31, 18007-18012 (2011).
  16. Castellano, J.M., et al. Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance. Sci. Transl. Med. 3, 89ra57 (2011).
  17. Kim, J. & Holtzman, D.M. Prion-like behavior of amyloid-beta. Science 330, 918-919 (2010).
  18. Basak, J.M. & Kim, J. Differential effects of ApoE isoforms on dendritic spines in vivo: linking an Alzheimer's disease risk factor with synaptic alterations. J. Neurosci. 30, 4526-4527 (2010).
  19. Kim, J., et al. Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular Abeta clearance. Neuron 64, 632-644 (2009).
  20. Kim, J., Basak, J.M. & Holtzman, D.M. The role of apolipoprotein E in Alzheimer's disease. Neuron 63, 287-303 (2009).
  21. Kim, J., et al. BRI2 (ITM2b) Inhibits Abeta Deposition In Vivo. J Neurosci. 28, 6030-6036 (2008).
  22. Kim, J., et al. Abeta40 inhibits amyloid deposition in vivo. J. Neurosci. 27, 627-633 (2007).
  23. McGowan, E., et al. Abeta42 is essential for parenchymal and vascular amyloid deposition in mice. Neuron 47, 191-199 (2005).

Titles & Appointments

  • P. Michael Conneally Professor of Medical and Molecular Genetics
  • Education
    2010 Postdoctoral Training Washington University School of Medicine
    2006 PhD Mayo Clinic College of Medicine & Science
    2000 BS Pohang University of Science and Technology
  • Research

    Dr. Kim’s laboratory is interested in understanding the molecular and cellular basis of neuronal and glial dysfunction in Alzheimer’s disease, other aging-associated neurodegenerative diseases, and normal brain aging. Our primary goal is to develop therapeutic strategies for Alzheimer’s disease by targeting Apolipoprotein (ApoE) and ApoE-regulating proteins, such as ATP-binding cassette transporter A1 (ABCA1) and low density lipoprotein receptor (LDLR). We are also investigating the roles of multiple genes selectively expressed in microglia, such as ABI Family Member 3 (ABI3), in the pathogenesis of Alzheimer’s disease.

    Another line of research aims to study the role of epigenetics and non-coding RNAs in Alzheimer’s disease. Emerging transcriptomics technologies recently revealed that many non-coding regions actually encode functional RNAs, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). Using cell culture, animal models, and systems biology approaches, we study non-coding RNAs that may play critical roles in neurodegenerative diseases and brain aging. In addition, we are investigating whether microRNAs of our interest affect cardiovascular diseases, obesity, and diabetes.

    Keywords: Alzheimer's disease, Transcriptomics, Proteomics, Epigenetics, Systems biology, QTL mapping, CRISPR screening, Drug discovery (ASO, Gene therapy & Small molecules), non-coding RNAs (microRNAs & LncRNAs), Model systems (Mouse, Human iPSC, & Drosophila)
  • Awards
    Org: Alzheimer’s Drug Discovery Foundation
    Desc: Outstanding Young Investigator Award
    Scope: International
    Org: Charleston Conference on Alzheimer’s disease
    Desc: The New Vision Award
    Scope: National
    Org: The Association of Korean Neuroscientists
    Desc: Outstanding Junior Faculty Award
    Scope: International

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