Faculty

Bo Zhao, PhD

Assistant Professor of Otolaryngology-Head & Neck Surgery

Phone (317) 278-1215

Address

Glick Eye Institute, Room 318
1160 W. Michigan Street

Indianapolis, IN 46202

Bio

Bo Zhao, PhD, was appointed Assistant Professor of Otolaryngology—Head and Neck Surgery in December 2016. He joined Indiana University School of Medicine faculty after working with Dr. Ulrich Müller at The Scripps Research Institute in La Jolla, California. With a doctorate in Neurobiology, Dr. Zhao is most interested to identify novel molecules and pathways required for auditory perceptions. His research goal is to develop new therapeutic treatment for some forms of sensorineural hearing loss, caused by defects in cochlear hair cells.

Dr. Zhao recently received funding from the National Institute on Deafness and Other Communication Disorders (NIDCD) for his research, titled, “Fam65b function in hearing and deafness.” He continues his research in the Laboratory of Molecular Mechanisms of Auditory Perception and Deafness, located in the Glick Eye Institute on the IUPUI campus.

Laboratory: Molecular Mechanisms of Auditory Perception and Deafness

Titles & Appointments

Assistant Professor of Otolaryngology-Head & Neck Surgery

Education

2011 PhD Chinese Academy of Sciences

2004 BS Shandong University
Publications

A <i>RIPOR2</i> in-frame deletion is a frequent and highly penetrant cause of adult-onset hearing loss.
de Bruijn SE; Smits JJ; Liu C; Lanting CP; Beynon AJ; Blankevoort J; Oostrik J; Koole W; de Vrieze E; Cremers CWRJ; Cremers FPM; Roosing S; Yntema HG; Kunst HPM; Zhao B; Pennings RJE; Kremer H; DOOFNL Consortium.; Journal of medical genetics 2020 Jul 6

TMIE Defines Pore and Gating Properties of the Mechanotransduction Channel of Mammalian Cochlear Hair Cells.
Cunningham CL; Qiu X; Wu Z; Zhao B; Peng G; Kim YH; Lauer A; Müller U; 2020 Apr 16

GRXCR2 Regulates Taperin Localization Critical for Stereocilia Morphology and Hearing.
Liu C; Luo N; Tung CY; Perrin BJ; Zhao B; Cell reports 2018 Oct 30

Mechanotransduction by PCDH15 Relies on a Novel cis-Dimeric Architecture.
Dionne G; Qiu X; Rapp M; Liang X; Zhao B; Peng G; Katsamba PS; Ahlsen G; Rubinstein R; Potter CS; Carragher B; Honig B; Müller U; Shapiro L; Neuron 2018 Jul 26

The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells.
Cunningham CL; Wu Z; Jafari A; Zhao B; Schrode K; Harkins-Perry S; Lauer A; Müller U; eLife 2017 May 15

Mechanosensory hair cells express two molecularly distinct mechanotransduction channels.
Wu Z; Grillet N; Zhao B; Cunningham C; Harkins-Perry S; Coste B; Ranade S; Zebarjadi N; Beurg M; Fettiplace R; Patapoutian A; Mueller U; Nature neuroscience 2016 Nov 28

Murine Fam65b forms ring-like structures at the base of stereocilia critical for mechanosensory hair cell function.
Zhao B; Wu Z; Müller U; eLife 2016 Jun 8

PDZD7-MYO7A complex identified in enriched stereocilia membranes.
Morgan CP; Krey JF; Grati M; Zhao B; Fallen S; Kannan-Sundhari A; Liu XZ; Choi D; Müller U; Barr-Gillespie PG; eLife 2016 Aug 15

The elusive mechanotransduction machinery of hair cells.
Zhao B; Müller U; Current opinion in neurobiology 2015 Sep 3

TMIE is an essential component of the mechanotransduction machinery of cochlear hair cells.
Zhao B; Wu Z; Grillet N; Yan L; Xiong W; Harkins-Perry S; Müller U; Neuron 2014 Nov 20

Subunit determination of the conductance of hair-cell mechanotransducer channels.
Beurg M; Xiong W; Zhao B; Müller U; Fettiplace R; Proceedings of the National Academy of Sciences of the United States of America 2014 Dec 30

TMHS is an integral component of the mechanotransduction machinery of cochlear hair cells.
Xiong W; Grillet N; Elledge HM; Wagner TF; Zhao B; Johnson KR; Kazmierczak P; Müller U; Cell 2012 Dec 7

Facilitation of µ-opioid receptor activity by preventing d-opioid receptor-mediated codegradation.
He SQ; Zhang ZN; Guan JS; Liu HR; Zhao B; Wang HB; Li Q; Yang H; Luo J; Li ZY; Wang Q; Lu YJ; Bao L; Zhang X; Neuron 2011 Jan 13

Transport of receptors, receptor signaling complexes and ion channels via neuropeptide-secretory vesicles.
Zhao B; Wang HB; Lu YJ; Hu JW; Bao L; Zhang X; Cell research 2011 Feb 15

Coexpression of delta- and mu-opioid receptors in nociceptive sensory neurons.
Wang HB; Zhao B; Zhong YQ; Li KC; Li ZY; Wang Q; Lu YJ; Zhang ZN; He SQ; Zheng HC; Wu SX; Hökfelt TG; Bao L; Zhang X; Proceedings of the National Academy of Sciences of the United States of America 2010 Jul 6

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