27057-Zhang, Chi

Chi Zhang, PhD

Associate Professor of Medical & Molecular Genetics

410 W. 10th Street, HS 5000

Indianapolis, IN 46202
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Dr. Chi Zhang focuses on computational modeling of cancer micro-environment including the level of hypoxia, oxidative stress, acidity and dysregulation of extracellular matrix as well as altered immune responses in cancer tissue by using large scale omics data. Dr. Chi Zhang is also interested in developing novel computation methods to integrate multiple tissue level and single cell omics data types to understand the mechanism of cancer initiation, progression, metastasis and cancer tumor tissue’s resistance to certain therapies. In addition, his research application also includes inference of intra-tumor heterogeneity and reprogrammed metabolism, and prediction of gain or loss of functions led by a certain mutation or collective effect of multiple mutations. Chi Zhang's lab webpage: https://bdr.netlify.com

Titles & Appointments

  • Associate Professor of Medical & Molecular Genetics
  • Education
    2016 MS University of Georgia
    2015 PhD University of Georgia
    2010 BS Peking University
  • Research

    ?   Statistical and computational modelling of cancer initiation and progression, including energy metabolism reprogramming, interactions between cancer cells and microenvironment

    ?   Intra-tumor heterogeneity and its relationship with cancer associated micro-environmental stress

    ?   Prediction of gain or loss of function of certain mutations and interactive effect of multiple mutations

    ?   Develop statistical deconvolution method to predict the alterations of immune and stroma cells in tissue based omics data.

    ?   Develop novel computation methods to integrate multiple omics types to model the biological characteristics in progression of inflammatory diseases and cancer

    ?   Single cell RNA-Seq data analysis

    ?   Bi-clustering algorithm development

  • Awards
    Org: The University of Georgia
    Desc: Graduate student excellence-in-research award (Five recipients every year. Awarded as the recipient in Life Sciences)
    Scope: University
    Date: 2016-02-01

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