Matthew D. Durbin, MD, MS

Bio

Dr. Durbin is an Assistant Professor of Pediatrics at Indiana University School of Medicine. He received his undergraduate degree from Indiana University and did his medical training at Wright State University. After medical school, Dr. Durbin completed a residency in pediatrics at the Loyola University Chicago and a fellowship in Neonatal-Perinatal Medicine at Vanderbilt University in Nashville. He is an attending neonatologist providing clinical service in the ICU and CVICU at the Riley Hospital for Children, Eskenazi Hospital, and St. Francis Hospital in Indianapolis. He is also a basic scientist at the Wells Center for Pediatric Research, focusing on the genomics and developmental defects leading to congenital heart disease.

Key Publications

1) Denver D, Feinberg S, Steding C, Durbin M, and Lynch, M. The relative roles of three DNA repair pathways in preventing Caenorhabditis elegans mutation accumulation. Genetics 174.1 (2006): 57-65.

2) Michail S, Durbin M, Turner D, Griffiths A, Mack D, Hyams J, Leleiko N, Kenche H, Stolfi A, Wine E. Alterations in the gut microbiome of children with severe ulcerative colitis. Inflammatory Bowel Diseases 18.10 (2012): 1799-1808.

3) Durbin, M. D., Cadar, A. G., Williams, C. H., Guo, Y., Bichell, D. P., Su, Y. R., & Hong, C. C. (2017). Hypoplastic Left Heart Syndrome Sequencing Reveals a Novel NOTCH1 Mutation in a Family with Single Ventricle Defects. Pediatric Cardiology, 1-9.

4) Cadar, A. G.*, Feaster, T. K.*, Durbin, M. D.*, & Hong, C. C. (2017). Production of Single Contracting Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Matrigel Mattress Technique. Current Protocols in Stem Cell Biology, 4A-14. *Authors contributed equally to publication.

Titles & Appointments

Assistant Professor of Pediatrics

Education

2018 MS Indiana University

2016 FEL Neonatology Fellowship, Vanderbilt University Medical Center

2013 RES Pediatrics Residency, Loyola University Medical Center

2010 MD Wright State University

2006 BA&BS Indiana University
Research

Congenital heart disease is the most common birth defect, and a leading cause of death in the newborn period, yet etiology remains mostly unknown. During Neonatology Fellowship he used next generation sequencing and disease modeling with patient derived induced pluripotent stem cells to study the genetics and mechanism of congenital heart disease. After Fellowship Dr. Durbin joined the faculty at Indiana University and the lab of Dr. Stephanie Ware. He is using genomics, gene editing, animal models, and cell culture models to elucidate the developmental pathways and molecular mechanisms altered in structural heart disease. He is currently exploring the role of a gene called SHROOM3 in structural heart disease. He is also exploring the optimal clinical evaluation for newborns with heart disease in the ICU, including diagnostic testing using next generation sequencing, and whole exome sequencing.
Professional Organizations

American Academy of Pediatrics

Society for Pediatric Research
Board Certifications

American Board of Pediatrics - Pediatrics
Clinical Interests

Pediatrics, Neonatal-Perinatal Medicine, Congenital Heart Disease

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