Faculty

Kenneth P. Nephew, PhD

Jerry W. and Peggy S. Throgmartin Professor of Oncology

Phone (812) 855-9445

Address

Biology Building 302
MSCI
BL
Bloomington, IN 47405

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Bio

EDUCATION

1983, BS The Ohio State University (Animal Sciences)
1986, MS The Ohio State University (Dairy Science; Reproductive Physiology)
Effect of Prostaglandin F2 alpha on Lipoprotein Utilization in Cultured Bovine Luteal Cells
1991, PhD The Ohio State University (Animal Sciences; Reproductive Physiology)
Role of Embryonic Migration and Trophoblast Interferons on Maternal Recognition of Pregnancy

POSTDOCTORAL TRAINING

1991-1992 Postdoctoral Fellow, Department of Obstetrics and Gynecology University of Kansas School of Medicine (Center for Reproductive Medicine, Wichita)
1992-1996 NIH Postdoctoral Fellow, Department of Cancer Biology University of Cincinnati, College of Medicine

PROFESSIONAL EMPLOYMENT

Academic Appointments

1996-2002 Assistant Professor of Cellular and Integrative Physiology Indiana University School of Medicine
2002-2006 Associate Professor of Cellular and Integrative Physiology (tenure) Indiana University School of Medicine
2007-Present Professor of Cellular and Integrative Physiology
Adjunct Professor of Molecular and Cellular Biochemistry
Adjunct Professor of Obstetrics and Gynecology Indiana University School of Medicine

Titles & Appointments

Jerry W. and Peggy S. Throgmartin Professor of Oncology
Professor of Anatomy, Cell Biology & Physiology
Adjunct Professor of Obstetrics & Gynecology
Adjunct Professor of Biology, College of Arts & Sciences, IU Bloomington
Fellow, Indiana Molecular Biology Institute, College of Arts and Sciences, IU Bloomington

Education

1991 PhD The Ohio State University

1986 MS The Ohio State University

1983 BS The Ohio State University
Research

MAJOR RESEARCH INTERESTS

Women’s Cancers & Translational Research
Cancer Epigenetics (DNA methylation, histone modifications, non-coding RNAs)
Cancer Stem Cells
Nuclear receptors/steroid hormone action/hormone-associated cancers
Drug resistance (ovarian and breast cancers)
Publications

Long-range regulators of the lncRNA HOTAIR enhance its prognostic potential in breast cancer.
Milevskiy MJ; Al-Ejeh F; Saunus JM; Northwood KS; Bailey PJ; Betts JA; McCart Reed AE; Nephew KP; Stone A; Gee JM; Dowhan DH; Dray E; Shewan AM; French JD; Edwards SL; Clark SJ; Lakhani SR; Brown MA; Human molecular genetics 2016 Jul 4

BioVLAB-mCpG-SNP-EXPRESS: A system for multi-level and multi-perspective analysis and exploration of DNA methylation, sequence variation (SNPs), and gene expression from multi-omics data.
Chae H; Lee S; Seo S; Jung D; Chang H; Nephew KP; Kim S; Methods (San Diego, Calif.) 2016 Jul 28

NF-?B-HOTAIR axis links DNA damage response, chemoresistance and cellular senescence in ovarian cancer.
Özes AR; Miller DF; Özes ON; Fang F; Liu Y; Matei D; Huang T; Nephew KP; Oncogene 2016 Apr 4

Functional characterization of a panel of high-grade serous ovarian cancer cell lines as representative experimental models of the disease.
Haley J; Tomar S; Pulliam N; Xiong S; Perkins SM; Karpf AR; Mitra S; Nephew KP; Mitra AK; Oncotarget 2016 Apr 27

Regulation of triple-negative breast cancer cell metastasis by the tumor-suppressor liver kinase B1.
Rhodes LV; Tate CR; Hoang VT; Burks HE; Gilliam D; Martin EC; Elliott S; Miller DB; Buechlein A; Rusch D; Tang H; Nephew KP; Burow ME; Collins-Burow BM; Oncogenesis 2015 Oct 5

Carboplatin with Decitabine Therapy, in Recurrent Platinum Resistant Ovarian Cancer, Alters Circulating miRNAs Concentrations: A Pilot Study.
Benson EA; Skaar TC; Liu Y; Nephew KP; Matei D; PloS one 2015 Oct 20

Molecular determinants of chemotherapy resistance in ovarian cancer.
Cooley M; Fang P; Fang F; Nephew KP; Chien J; Pharmacogenomics 2015 Nov 10

Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer.
Bowtell DD; Böhm S; Ahmed AA; Aspuria PJ; Bast RC Jr; Beral V; Berek JS; Birrer MJ; Blagden S; Bookman MA; Brenton JD; Chiappinelli KB; Martins FC; Coukos G; Drapkin R; Edmondson R; Fotopoulou C; Gabra H; Galon J; Gourley C; Heong V; Huntsman DG; Iwanicki M; Karlan BY; Kaye A; Lengyel E; Levine DA; Lu KH; McNeish IA; Menon U; Narod SA; Nelson BH; Nephew KP; Pharoah P; Powell DJ Jr; Ramos P; Romero IL; Scott CL; Sood AK; Stronach EA; Balkwill FR; Nature reviews. Cancer 2015 Nov
Professional Organizations

American Association for Cancer Research

American Association for the Advancement of Science

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