Medical Science, Room MS1021D
Indianapolis, IN 46202
X. Charlie Dong, PhD, is a Professor in the Department of Biochemistry and Molecular Biology and investigator of Indiana University Center of Diabetes and Metabolic Diseases. Prior to his appointment at Indiana University, he got his B.S. in Biology from Shandong Normal University, M.S. in Genetics from Chinese Academy of Sciences Institute of Genetics and Developmental Biology, and Ph.D. in Molecular and Cellular and Developmental Biology from The Ohio State University. He also received postdoctoral training in diabetes and metabolism from Joslin Diabetes Center and Children's Hospital Boston of Harvard Medical School. He was promoted to instructor in pediatrics at Harvard Medical School.
A complete list of published work is available.
Morral N, Liu S, Conteh AM, Chu X, Wang Y, Dong XC, Liu Y, Linnemann AK, Wan J. Aberrant gene expression induced by a high fat diet is linked to H3K9 acetylation in the promoter-proximal region. Biochim Biophys Acta Gene Regul Mech. 2021 Mar;1864(3):194691. [PMID: 33556624]
Tao Z, Shi L, Parke J, Zheng L, Gu W, Dong XC, Liu D, Wang, Z, Olumi AF, Cheng Z. Sirt1 coordinates with ERα to regulate autophagy and adiposity. Cell Death Discov. 2021 Mar 15;7(1):53. [PMID: 33723227]
Fang Z, Kim HG, Huang M, Chowdhury K, Li MO, Liangpunsakul S, Dong XC. Sestrin proteins protect against lipotoxicity-induced oxidative stress in the liver via suppression of C-Jun N-terminal kinases. Cell Mol Gastroenterol Hepatol. 2021 May 4:S2352-345X(21)00086-2. [PMID: PMID: 33962074]
Misra J, Holmes MJ, Mirek ET, Langevin M, Kim HG, Carlson KR, Watford M, Dong XC, Anthony TG, Wek, RC. Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress. Nucleic Acids Res. 2021 Jun 4;49(10):5726-5742. [PMID: 34023907]
Xu L, Zhang X, Xin Y, Ma J, Yang C, Zhang X, Hou G, Dong XC, Sun Z, Xiong X, Cao X. Depdc5 deficiency exacerbates alcohol-induced hepatic steatosis via suppression of PPARα pathway. Cell Death Dis. 2021 Jul 15;12(7):710. [PMID: 34267188]
Dong XC. PNPLA3-A Potential Therapeutic Target for Personalized Treatment of Chronic Liver Disease. Front Med (Lausanne). 2019 Dec 17;6:304. doi: 10.3389/fmed.2019.00304. eCollection 2019. Review.
Vemuri S, Srivastava R, Mir Q, Hashemikhabir S, Dong XC, Janga SC. SliceIt: A genome-wide resource and visualization tool to design CRISPR/Cas9 screens for editing protein-RNA interaction sites in the human genome. Methods. 2019 Sep 5. pii: S1046-2023(19)30111-2. doi: 10.1016/j.ymeth.2019.09.004. [Epub ahead of print]
Liu Y, Kim HG, Dong E, Dong C, Huang M, Liu Y, Liangpunsakul S, Dong XC. Sesn3 deficiency promotes carcinogen-induced hepatocellular carcinoma via regulation of the hedgehog pathway. Biochim Biophys Acta Mol Basis Dis. 2019 Oct 1;1865(10):2685-2693. doi: 10.1016/j.bbadis.2019.07.011. Epub 2019 Jul 24.
Kim HG, Huang M, Xin Y, Zhang Y, Zhang X, Wang G, Liu S, Wan J, Ahmadi AR, Sun Z, Liangpunsakul S, Xiong X, Dong XC. The epigenetic regulator SIRT6 protects the liver from alcohol-induced tissue injury by reducing oxidative stress in mice. J Hepatol. 2019 Nov;71(5):960-969. doi: 10.1016/j.jhep.2019.06.019. Epub 2019 Jul 8.
Huang M, Kim HG, Zhong X, Dong C, Zhang B, Fang Z, Zhang Y, Lu X, Saxena R, Liu Y, Zhang C, Liangpunsakul S, Dong XC. Sestrin 3 Protects Against Diet-Induced Nonalcoholic Steatohepatitis in Mice Through Suppression of Transforming Growth Factor β Signal Transduction. Hepatology. 2020 Jan;71(1):76-92. doi: 10.1002/hep.30820. Epub 2019 Sep 27.
Tao R, Wang C, Stöhr O, Qiu W, Hu Y, Miao J, Dong XC, Leng S, Stefater M, Stylopoulos N, Lin L, Copps KD, White MF. Inactivating hepatic follistatin alleviates hyperglycemia. Nat Med. 2018 Oct;24(10):1628. doi: 10.1038/s41591-018-0129-0.
For a complete list of publications, visit PubMed
Titles & Appointments
- Professor of Biochemistry & Molecular Biology
- Adjunct Professor, School of Informatics and Computing